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Cell cycle regulation in cancer: A noncoding perspective

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Title: Cell cycle regulation in cancer: A noncoding perspective
Authors: Ali, Mohamad
Issue Date: 26-Nov-2019
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Biochemistry and Cell Biology
Parts of work: 1-Meryet-Figuiere M, Alaei-Mahabadi B, Ali MM, Mitra M, Subhash S, Pandey GK, Larsson E, and Kanduri C. “Temporal separation of replication and transcription during S-phase progression” 2014, Cell Cycle, 13: 3241-8.

2-Ali MM*, Akhade VS*, Kosalai ST*, Subhash S*, Statello L, Meryet-Figuiere M, Abrahamsson J, Mondal T and Kanduri C. “PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers” 2018, Nature Communications, 9: 883. *Authors contrinuted equally

3-Statello L, Ali MM, Reischl S, Kosalai ST, Akhade VS, and Kanduri C. “SCAT7 lncRNA regulates TOP1 turnover and DNA homology-directed repair in lung cancer”. Manuscript

4-Ali MM, Mahale S, Marco M, Kosalai ST, Mishra K, Statello L, Umpathy G, Hallberg B, and Kanduri C. “LY6K-AS lncRNA regulates mitotic progression and chemoresistance in lung adenocarcinoma cells”. Manuscript
Date of Defence: 2019-12-17
Disputation: Tisdagen, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Long Noncoding RNA
Cell cycle
S phase
Abstract: The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. However, the cell cycle regulation has always been associated with a “protein-centric” view that implicates an intricate network of closely related proteins and transcription factors. This view neglects the fact that only 2 ̶ 2.3% of the human genome codes for proteins. On the ... more
ISBN: 978-91-7833-720-0 (PRINT)
978-91-7833-721-7 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin



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