Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi by Title
Now showing items 95-114 of 205
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Lanthanide-mediated C-F Bond Activation Method Development and Mechanistic Investigation
(2016-08-23)The use of transition-metals and main-group Lewis acids has proven to be an outstanding source for activation and subsequent functionalization of fluorinated compounds. However, the first is mainly limited to C(sp2)–F bonds ... -
Laser Scanning Multiphoton Microscopy – Focusing on Fluorescence Correlation Spectroscopy and Fluorescence Lifetime Imaging for Biomedical Applications
(2022-03-02)Laser scanning multiphoton microscopy (MPM) is considered as a non-invasive technology for three-dimensional imaging of complex biological tissues. The quantitative potential of the MPM is not investigated as much as ... -
Light and X-ray scattering investigations of microtubules subjected to oscillating electric fields
(2022-12-08)I vårt dagliga liv blir vi utsatta för oscillerande elektriska fält av olika frekvenser. Dessa fält inkluderar mobiltelefoner, wifi, bluetooth, radar för navigering, radar från bilar, kommunikationssatelliter, samt GPS. ... -
Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae
(2014-03-07)Proteins are continuously synthesized and degraded to meet the demands of the cell. Hence, a proper balance between synthesis, folding, disaggregation and degradation is of essence to ensure cell survival. Disruption of ... -
Lipidic Cubic Phase Microcrystallization and its Application in Serial Crystallography
(2020-10-23)Every living organism contain a cell membrane which is an important cell structure with a vast variety of different functions such as cell signaling, transportation and energy production. One of the most important functions ... -
LOOK AROUND, WHAT CAN YOU DISCOVER? The science center - a critical space for science student teachers’ development
(2021-04-21)This thesis aims to examine the opportunities and constraints on student teachers’ learning of science and teaching science when they work in small groups; planning, implementing, and reflecting upon teaching at the ... -
Low biocide emission antifouling based on a novel route of barnacle intoxication
(2013-05-17)Marine biofouling can be defined as the colonization of man-made surfaces in seawater by microscopic and macroscopic organisms. This phenomenon can result in great loss of function and effectiveness both for cruising ships ... -
Mapping ultrastructural effects of proteotoxic stress on S. cerevisiae
(2023-05-09)Cells are the basic building blocks of any living being, whether the organism consists of only one, or many cells. The different cellular components interact with one another to maintain the viability of the cell. An ... -
Mass spectrometry based analysis of drugs, neurotransmitters and lipids in invertebrate model systems
(2015-09-07)Mass spectrometry (MS) is one of the most universal analytical techniques due to its label-free detection principle and high chemical specificity, high selectivity, and sensitivity. MS is diverse with many different types ... -
Mechanistic Insights into Transition Metal Oxide Catalyzed Water Oxidation
(2012-05-14)A binuclear mechanism was proposed and evaluated by means of Density Functional Theory calculations. The central reaction steps were found to be the oxidation of the transition metal TM-OH moieties to TM=O and the subsequent ... -
Membrane Fluidity Regulation: From C. elegans to mammalian cells
(2020-08-12)Biological membranes are primarily an assembly of lipids and proteins. Collectively, these constituents within a phospholipid bilayer determine the physical membrane properties such as fluidity, viscosity, thickness, packing ... -
Membrane morphology and homeostasis: An electron microscopy approach
(2023-06-26)Biological membranes allow life as we know it to exist. Primarily assembled from lipids and proteins, their morphology and function can greatly vary between species or even within the same cell. They create physical ... -
Micro-Crystallization and Time-Resolved Diffraction Studies of a Bacterial Photosynthetic Reaction Center
(2019-05-27)Photosynthesis is one of the most important set of chemical reactions in nature as they can convert sunlight into hydrocarbons and chemical energy. The proteins responsible for this are two general types of reaction centers ... -
Microbial communities in anammox and nitrifying biofilms
(2017-09-19)Excess of nitrogen in water bodies causes eutrophication. One important source of nitrogen is the effluent from wastewater treatment plants (WWTPs). Nitrogen in wastewater is most commonly removed by nitrification-denitrification. ... -
Microcrystallization and structural studies of proteins by serial crystallography and x-ray scattering
(2023-09-20)Proteins are the most complex and versatile biomolecules known, with essential roles in all cellular and physiological processes. They constitute the main structural components of cells, catalyze most biochemical reactions, ... -
Microcrystallization in lipidic cubic phase and serial crystallography studies of cytochrome c oxidase
(2019-11-07)Life in all living organisms depend on chemical processes performed by proteins, which are molecular machineries encoded in the DNA. Cytochrome c oxidase (CcO) is a membrane protein essential for cellular respiration, a ... -
Microtubule structure and function as perturbed by electromagnetic fields
(2022-11-08)Frontlinjen för strukturbiologisk forskning ligger idag i att avbilda proteiner i rörelse. För att förstå hur proteiner fungerar rent strukturellt krävs avbildningsmetoder med en tid- och rums-upplösning anpassad för den ... -
Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational approach
(2019-12-12)Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease that is the major mediator of the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress. The association ... -
Modulating Sirtuin Activity - Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors
(2014-11-21)Sirtuins (SIRTs) are NAD+-dependent lysine deacetylating enzymes targeting histones and a multitude of non-histone proteins. The SIRTs have been related to important cellular processes such as gene expression, cell ... -
Molecular biology of barnacle Balanus improvisus settlement
(2019-09-13)The aim of this thesis was to investigate molecular mechanisms of various aspects of barnacle settlement, using the acorn barnacle Balanus improvisus. This barnacle is a common fouling species and a model organism for ...