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Pan-cancer study of transcriptional responses to oncogenic somatic mutations
(2021-05-27)
Cancer cells typically carry acquired somatic mutations in key cancer driver genes, which can be identified on the basis of recurrence in cancer cohorts. Such mutations may cause aberrant protein activity and altered gene ...
Membranous Nephropathy - Challenges in diagnostics and treatment
(2016-04-04)
The variability in the pathogenesis, clinical presentation and outcome of membranous nephropathy (MN) poses major clinical challenges and raises different questions, both regarding diagnostics and treatment of patients ...
Pathophysiological impact of targeting the ROS-p53 axis
(2014-10-21)
The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using ...
Using genetics to identify epigenetic and signal transduction targets in cancer
(2016-05-12)
Cancer arises mostly due to the stepwise acquisition of untamed growth
capabilities by various means, ranging from genetic, epigenetic to
environmental factors. With the advancement made in molecular biology and
associated ...
Computational studies of mutational sequence signatures in cancer genomes
(2021-10-08)
Cancer typically forms when mutational processes modify key cancer driver genes, resulting in positive selection and tumor growth. As such, mutational processes are at the core of the disease. Trinucleotide mutational ...
Effects of antioxidant supplementation on cancer progression
(2018-05-18)
Popular wisdom holds that antioxidants protect against cancer because they neutralize reactive oxygen species (ROS) and other free radicals which can otherwise cause cancer by damaging DNA. This has been the rationale ...
Elevated calcium concentration, is it dangerous? Long-term follow-up in primary care
(2014-02-12)
Background and aims: Patients with hypercalcaemia are relatively common in primary care; the most frequent causes are primary hyperparathyroidism (pHPT) and cancer. Many patients with pHPT have such discrete symptoms that ...
Multiparametric MRI for evaluation of tumour treatment response
(2016-11-18)
Clinical assessment of tumour response to treatment largely relies on estimates of tumour size
by, e.g., measuring the largest tumour diameters on magnetic resonance (MR) or computed
tomography (CT) images, weeks or ...
Molecular characterization of neuroblastoma tumors - a basis for personalized medicine.
(2012-05-24)
Neuroblastoma is a very heterogeneous tumor, with a clinical course ranging from spontaneous regression to aggressive tumor growth. A proper stratification of the patients into different risk groups is therefore important ...
Barretts esophagus - aspects on early detection of malignant transformation
(2016-10-20)
Background: Barrett’s esophagus (BE) is a metaplastic mucosal transformation adjacent to the gastroesophageal junction, due to chronic reflux of gastric juices. BE is associated to an increased risk of esophageal adenocarcinoma ...