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Pan-cancer study of transcriptional responses to oncogenic somatic mutations

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Title: Pan-cancer study of transcriptional responses to oncogenic somatic mutations
Authors: Ashouri, Arghavan
Issue Date: 27-May-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Biochemistry and Cell Biology
Parts of work: I. Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events. Ashouri A, Sayin VI, Van den Eynden J, Singh SX, Papagiannakopoulos T, Larsson E. Nat Commun. 2016 Oct 25;7:13197.

II. Genome-wide characterization of the NRF2 targetome. Ashouri A, Larsson E. Manuscript

III. Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways. Van den Eynden J, Umapathy G, Ashouri A, Cervantes-Madrid D, Szydzik J, Ruuth K, Koster J, Larsson E, Guan J, Palmer RH, Hallberg B. Sci Signal. 2018 Nov 20;11(557).

Date of Defence: 2021-06-18
Disputation: Fredagen den 18 juni 2021, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Cancer
Driver mutations
Abstract: Cancer cells typically carry acquired somatic mutations in key cancer driver genes, which can be identified on the basis of recurrence in cancer cohorts. Such mutations may cause aberrant protein activity and altered gene expression in the nucleus, driving the cell toward a cancerous phenotype. Understanding the transcriptional consequences of cancer driver mutations can guide us towards better diagnosis and prognosis. While the phenotypic effects of driver mutations are typically mediated by ... more
ISBN: 978-91-8009-318-7 (PRINT)
978-91-8009-319-4 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin



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