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Using genetics to identify epigenetic and signal transduction targets in cancer


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/42347

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Title: Using genetics to identify epigenetic and signal transduction targets in cancer
Authors: Bhadury, Joydeep
E-mail: joydeep.bhadury@gu.se
Issue Date: 12-May-2016
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Surgery
Parts of work: Bhadury J, López MD, Muralidharan SV, Nilsson LM, Nilsson JA*. Identification of tumorigenic and therapeutically actionable mutations in transplantable mouse tumor cells by exome sequencing. Oncogenesis. 2013 Apr 15;2:e44.
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Einarsdottir BO, Bagge RO, Bhadury J, Jespersen H, Mattsson J, Nilsson LM, Truvé K, López MD, Naredi P, Nilsson O, Stierner U, Ny L, Nilsson JA*. Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions. Oncotarget. 2014 Oct 30;5(20):9609-18.
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Bhadury J*, Einarsdottir BO, Podraza A, Olofsson Bagge R, Stierner U, Ny L, Dávila López M, Nilsson JA*. Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived xenografts. Oncotarget. 2016 Mar 18.
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Bhadury J, Nilsson LM, Muralidharan SV, Green LC, Li Z, Gesner EM, Hansen HC, Keller UB, McLure KG, Nilsson JA*. BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2721-30.
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Muralidharan SV, Bhadury J, Nilsson LM, Green LC, McLure KG, Nilsson JA*. BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells. Oncogene. 2016 Jan 25
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Date of Defence: 2016-06-09
Disputation: Torsdagen den 9 juni 2016, kl 9.00, Hörsal Arvid Carlsson, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Cancer
BETi
HDACi
ATRi
miRNA
NGS
PDX
CDX
Abstract: Cancer arises mostly due to the stepwise acquisition of untamed growth capabilities by various means, ranging from genetic, epigenetic to environmental factors. With the advancement made in molecular biology and associated fields, the complex biological circuits leading to these pathological conditions have now started to be deciphered in-depth. In the present thesis I have shown that mouse exome sequencing may be used to guide targeted therapy in animal models (Paper I). In this study, we... more
ISBN: 978-91-628-9850-2 (PRINT)
978-91-628-9851-9 (PDF)
URI: http://hdl.handle.net/2077/42347
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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