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Computational studies of mutational sequence signatures in cancer genomes

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Title: Computational studies of mutational sequence signatures in cancer genomes
Authors: Lindberg, Markus
Issue Date: 8-Oct-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Biochemistry and Cell Biology
Parts of work: 1. Lindberg M., Boström M., Elliott K., Larsson E. Intragenomic variability and extended sequence patterns in the mutational signature of ultraviolet light. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20411-20417.

2. Lindberg M., Larsson E. An extended mutational signature model reveals contextual motifs informative of local mutation rate in cancer. Manuscript

3. Elias E., Ardalan A., Lindberg M., Reinsbach S., Muth A., Nilsson O., Arvidsson A., Larsson E. Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine. Accepted in Nat Comm
Date of Defence: 2021-11-04
Disputation: Torsdagen den 4 november 2021, kl 09.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Cancer
Mutational signatures
Ultraviolet light
Multifocal tumors
Abstract: Cancer typically forms when mutational processes modify key cancer driver genes, resulting in positive selection and tumor growth. As such, mutational processes are at the core of the disease. Trinucleotide mutational signatures have emerged in the last decade as essential tools for analysis of mutational processes. These models describe the relative probability of mutagenesis at different trinucleotide contexts for a variety of mutational processes. In UV exposed cancers, the DNA sequence “TTC... more
ISBN: 978-91-8009-508-2 (PRINT)
978-91-8009-509-9 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin



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