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Now showing items 11-18 of 18
The role of microglia in Alzheimer's disease - Investigating mechansims regulating amyloid-β clearance
(2016-05-31)
Alzheimer’s disease (AD) is the most common form of dementia today. The disease is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain, accompanied by a progressive neurodegeneration ...
Development of MALDI Mass Spectrometry Imaging Methods for Probing Spatial Lipid Biochemistry of Amyloid Plaques in Alzheimer's Disease
(2020-05-18)
Alzheimer’s disease (AD) is the most prevalent cause of neurodegenerative
dementia. Aggregation of amyloid β (Aβ) peptides into extracellular Aβ
plaques is one of the major neuropathological features of AD. However,
Aloysius ...
Subjective cognitive decline in memory clinic patients - characteristics and clinical relevance
(2017-05-12)
Subjective cognitive decline (SCD) refers to concerns – symptoms - regarding one’s
cognitive functioning, in the absence of objective evidence of impairment. SCD has
been described as a possible stage preceding mild ...
Synaptic elimination and the complement system in Alzhaimer's disease
(2012-08-23)
The mechanisms behind Alzheimer’s disease (AD) are largely unknown. The disease is to a large extent hereditary, and the best pathophysiological correlate to the severity of the symptoms is loss of synapses.
The general ...
Risk factors for dementia. Lifestyle, hormones, neurochemistry, and genetics
(2021-05-12)
Objective: The aim of this thesis was to expand the understanding about the effects of lifestyle factors, indicators of endogenous estrogens, and genetic factors on the risk of dementia and cerebrospinal fluid (CSF) markers ...
Biochemical markers in dementia - Exploring Swedish registry data and the human proteome
(2019-09-04)
Cerebrospinal fluid (CSF) biomarkers of neurodegenerative diseases have a wide scope of applications in diagnostics, prognosis assessment, disease staging, treatment evaluation and more. In this PhD project we aimed to ...
Quantitative neuroproteomics for biomarker discovery in Alzheimer's disease
(2014-01-17)
Alzheimer’s disease (AD) is the most common form of dementia characterized by amyloid plaques and neurofibrillary tangles in the brain. Novel biomarkers for AD are needed that reflect disease progression and could identify ...
Deriving biomarkers from computed tomography using deep learning
(2022-09-23)
X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are widely used structural neuroimaging modalities. For brain atrophy assessment and volumetric quantification using automated methods, MRI is the preferred ...