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Risk factors for dementia. Lifestyle, hormones, neurochemistry, and genetics


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Title: Risk factors for dementia. Lifestyle, hormones, neurochemistry, and genetics
Authors: Najar, Jenna
E-mail: jenna.najar@gu.se
Issue Date: 12-May-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: I. Najar J, Aakre A.J, Vassilaki M, Wetterberg H, Rydén L, Zettergren A, Skoog I, Jack C.R, Knopman D.S, Petersen R.C, Kern S, Mielke M.M. Sex differences in the relation between marital status and dementia risk in two population-based cohorts. (submitted manuscript)

II. Najar J, Östling S, Gudmundsson P, Sundh V, Johansson L, Kern S, Guo X, Hällström T, Skoog I. Cognitive and physical activity and dementia: A 44-year longitudinal population study of women. Neurology. 2019 Mar 19;92(12):e1322-e1330.
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III. Najar J, Östling S, Waern M, Zettergren A, Kern S, Wetterberg H, Hällström T, Skoog I. Reproductive period and dementia: A 44-year longitudinal population study of Swedish women. Alzheimers Dement. 2020 Aug;16(8):1153-1163.
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IV. Najar J, Hällström T, Zettergren A, Johansson L, Joas E, Mellqvist Fässberg M, Zetterberg H, Blennow K, Kern S, Skoog I. Reproductive period and preclinical cerebrospinal fluid markers for Alzheimer’s disease: A 25-year study. (Accepted for publication in Menopause)

V. Najar J, van der Lee S.J, Joas E, Wetterberg H, Hardy J, Guerreiro R, Bras J, Waern M, Kern S, Zetterberg H, Blennow K, Skoog I, Zettergren A. Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives. Alzheimers Dement (Amst). 2021 Jan 22;13(1):e12142.
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Date of Defence: 2021-06-11
Disputation: Fredagen den 11 juni 2021, kl.13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg. https://gu-se.zoom.us/j/69447521405?pwd=VFJGNFVrUDFYN2dEN0NOZytBbk5OUT09
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Dementia
Alzheimer's disease
Epidemiology
Marital status
Leisure time activity
Menopause
Polygenic risk scores
APOE genotype
Abstract: Objective: The aim of this thesis was to expand the understanding about the effects of lifestyle factors, indicators of endogenous estrogens, and genetic factors on the risk of dementia and cerebrospinal fluid (CSF) markers for Alzheimer’s disease (AD). Method: We used population-based samples from the Gothenburg H70 Birth Cohort Studies (H70-studies), the Prospective Population Study of Women (PPSW), and the Mayo Clinic Study of Aging (MCSA 70+ study). Information on exposures (marital status ... more
ISBN: 978-91-8009-274-6 (PRINT)
978-91-8009-275-3 (PDF)
URI: http://hdl.handle.net/2077/68059
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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