GUPEA >
Sahlgrenska Academy / Sahlgrenska akademin >
Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi >
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi >

Biochemical markers in dementia - Exploring Swedish registry data and the human proteome


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/60288

Files in This Item:

File Description SizeFormat
gupea_2077_60288_1.pdfThesis frame4883KbAdobe PDF
View/Open
gupea_2077_60288_2.pdfAbstract323KbAdobe PDF
View/Open
Title: Biochemical markers in dementia - Exploring Swedish registry data and the human proteome
Authors: Skillbäck, Tobias
E-mail: tobias.skillback@gu.se
Issue Date: 4-Sep-2019
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: I. Skillbäck T, Farahmand B Y, Rosén C, Mattsson N, Nägga K, Kilander L, Religa D, Wimo A, Winblad B, Schott J M, Blennow K, Eriksdotter M and Zetterberg H. Cerebrospinal fluid tau and amyloid–β1-42 in patients with dementia. Brain 2015, 138; 2716-2731
VIEW ARTICLE


II. Skillbäck T, Farahmand B Y, Bartlett J W, Rosén C, Mattsson N, Nägga K, Kilander L, Religa D, Wimo A, Winblad B, Rosengren L, Schott J M, Blennow K, Eriksdotter M, and Zetterberg H. CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival. Neurology, 2014, 83:1945-1953
VIEW ARTICLE


III. Skillbäck T, Rosén C, Asztely F, Mattsson N, Blennow K and Zetterberg H. Diagnostic performance of cerebrospinal fluid total tau and phosphorylated tau in Creutzfeldt-Jakob disease – Results from the Swedish mortality registry. JAMA Neurology 2014, 71(4):476-483
VIEW ARTICLE


IV. Skillbäck T, Mattson N, Hansson K, Mirgorodskaya E, Dahlén R, van der Flier W, Scheltens P, Duits F, Hansson O, Teunissen C, Blennow K, Zetterberg H and Gobom J. A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer’s disease. Scientific reports 2017, 7:13333
VIEW ARTICLE

Date of Defence: 2019-09-26
Disputation: Torsdagen den 26 september 2019, kl 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Biomarkers
Dementia
Alzheimer's disease
Vascular dementia
Creutzfeldt Jakob disease
Lewy body dementia
Frontotemporal dementia
Parkinson's disease dementia
Abstract: Cerebrospinal fluid (CSF) biomarkers of neurodegenerative diseases have a wide scope of applications in diagnostics, prognosis assessment, disease staging, treatment evaluation and more. In this PhD project we aimed to expand the understanding of the properties of known CSF biomarkers of Alzheimer’s disease (AD) and other neurodegenerative diseases, including the most prevalent dementia disorders. In study I, we explored CSF concentrations of three hallmark biomarkers of AD (amyloid β 1-42 [Aβ1... more
ISBN: 978-91-7833-525-1 (PDF)
978-91-7833-524-4 (PRINT)
URI: http://hdl.handle.net/2077/60288
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

© Göteborgs universitet 2011