Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 358-377 of 609
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Molecular Monitoring of Chronic Myeloid Leukemia Treated with Imatinib Mesylate
(2007-08-15)The BCR-ABL fusion gene product is a constitutively activated tyrosine kinase, which is fundamental in the pathogenesis of chronic myeloid leukemia (CML). Imatinib mesylate (imatinib, Glivec® or Gleevec®), a small molecule ... -
Monitoring of coagulation and platelet function in paediatric cardiac surgery
(2013-12-10)Abstract Background: Paediatric cardiac surgery has developed dramatically during the last decades. Today, a wide range of patients is operated on-from premature neonates to grown up children with congenital heart disease. ... -
Mortality and morbidity in patients with Addison's disease
(2015-02-27)Addison's disease (AD) or primary adrenal insufficiency is a rare disease with an estimated prevalence of 100-140 per million inhabitants and deadly unless treated with glucocorticoids (GCs). Very limited information is ... -
Myocardial creatine metabolism in experimental infarction and heart failure
(2007-10-04)The failing heart is characterized by changes in structure, function and metabolism. All these changes are usually defined as pathologic remodelling. An important part of this negative remodelling process is disturbances ... -
Myocardial ischemia and reperfusion injury, clinical and experimental studies
(2010-06-01)Acute myocardial infarction is the consequence of an occluded nutrient coronary artery. Reperfusion reduces infarct size and enhances the rate of survival. But reperfusion may also, in itself, cause reversible injury, ... -
Myocardial metabolism and ischemia assessed by microdialysis. Clinical and experimental studies in cardiac surgery
(2006-11-23)Background: The available methods to study myocardial metabolism and ischemia show considerable limitations when employed during and after cardiac surgery. Microdialysis is a technique for continuous sampling of substances ... -
Myocardial metabolism in experimental infarction and heart failure
(2008-02-15)Abstract The heart is an organ heavily dependent on exogenous lipids for the oxidative production of adenosine-triphosphate (ATP) and therefore maintenance of normal cellular energy homeostasis. However, high energy ... -
Myofibroblasts and polyploid cells in the conjunctival surface after allogeneic hematopoietic stem cell transplantation
(2011-05-09)Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment modality for hematological malignancies, such as leukemia and lymphoma. However, a major complication of the procedure is ... -
Nerve conduction and vibrotactile perception thresholds in female computer workers and hand-arm vibration-exposed male manual workers
(2010-10-22)Upper limb pain and disability are common problems, especially among working populations. The overall aim of this thesis was to investigate peripheral nerve function in the upper limb by nerve conduction test and vibration ... -
Neutrophil Function and Signaling Induced by Ligands for the Formyl Peptide Receptor 2
(2021-02-15)Neutrophil pattern recognition receptors belonging to the G-protein coupled receptor (GPCR) family play a role in the processes of initiation as well as resolution of inflammatory processes. Formyl peptide receptor 2 (FPR2) ... -
Neutrophil function in health and disease - role of intracellular radicals and galectin-3 as regulators of inflammation
(2013-11-14)The focus for this PhD project has been to investigate neutrophil functions in different (inflammatory) settings with specific focus on phagocyte-derived intracellular reactive oxygen species (ROS) as well as neutrophil ... -
New sensitive and specific methods for sex steroid measurements in rodent serum and tissues
(2023-11-23)Accurate measurement of sex steroids (androgens, estrogens, and progesterone) is essential in research and clinical settings for common diseases including osteoporosis, prostate cancer, breast cancer, and cardiovascular ... -
New-onset atrial fibrillation after coronary surgery: epidemiology, risk factors and long-term prognosis
(2024-04-25)Background and aim: New-onset postoperative atrial fibrillation (POAF) is common following coronary artery bypass grafting (CABG). Evidence on its prognostic implications, risk-stratification methods, and factors influencing ... -
Non-functioning pituitary adenomas and hypopituitarism - studies on morbidity and mortality
(2022-06-15)Background and aims: Hypopituitarism is most commonly caused by benign pituitary tumors, often resulting in insidious symptoms that develop over a long time. Due to either a mass effect exerted by the tumor, or due to the ... -
Non-functioning pituitary tumours - mortality, morbidity and tumour progression
(2014-04-16)Non-functioning pituitary tumours, i.e. non-functioning pituitary adenomas (NFPA) and craniopharyngiomas (CP), are histologically benign brain tumours. They are, however, associated with hypopituitarism, diabetes insipidus ... -
Non-invasive assessement of coronary flow velocity: Clinical and experimental studies
(2016-11-17)BACKGROUND AND OBJECTIVES Coronary flow velocity (CFV) and coronary flow velocity reserve (CFVR) evaluated by transthoracic ultrasound is a promising method to assess ischemic heart disease. CFVR is the ratio between ... -
Nonfatal injuries in a local context - Analysing social structures and perceptions in young people
(2012-05-24)Background: Injuries are a common health problem in children and young people. The uneven distribution over gender and socioeconomic groups is partly explained by factors at both the individual and family levels, but ... -
NOTUM and RSPO3 in Bone - WNT signaling modulators regulating the skeleton
(2023-05-02)Osteoporosis is a skeletal disease affecting millions of people worldwide, often leading to fragility fractures and a decreased quality of life. There is an unmet medical need for new anabolic, bone building, treatments. ... -
Nutritional impact on health in patients with Rheumatoid Arthritis
(2022-05-19)Objective: Rheumatoid Arthritis (RA) is the most common autoimmune rheumatic disease, affecting around 0.5-1% of the population. The aim of this thesis was to study dietary impact on markers of health in patients with ... -
Nutritional metabolomics: The search for dietary exposure variables
(2018-10-19)To establish associations and causation between diet and health, objective and reliable methods are needed to measure dietary exposure. Metabolomics provide an unbiased tool for exploring the modulation of the human ...