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Neutrophil Function and Signaling Induced by Ligands for the Formyl Peptide Receptor 2

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Title: Neutrophil Function and Signaling Induced by Ligands for the Formyl Peptide Receptor 2
Authors: Holdfeldt, André
Issue Date: 15-Feb-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Rheumatology and Inflammation Research
Parts of work: 1. André Holdfeldt, Agnes Dahlstrand Rudin, Michael Gabl, Zahra Rajabkhani, Gabriele M. König, Evi Kostenis, Claes Dahlgren, and Huamei Forsman, 2017, Reactivation of Gαi-coupled formyl peptide receptors is inhibited by Gαq selective inhibitors when induced by signals generated by the PAF receptor J Leukoc Biol.102(3):871-880.

2. André Holdfeldt, Sarah Line Skovbakke, Michael Gabl, Christina Nielsen, Claes Dahlgren, Henrik Franzyk, and Huamei Forsman. 2019, Structure–Function Characteristics and Signaling Properties of Lipidated Peptidomimetic FPR2 Agonists: Peptoid Stereochemistry and Residues in the Vicinity of the Headgroup Affect Function, ACS Omega 4 (3), 5968–5982.

3. André Holdfeldt, Simon Lind, Camilla Hesse, Claes Dahlgren, and Huamei Forsman. 2020, The PAR4-derived pepducin P4Pal10 lacks effect on neutrophil GPCRs that couple to Gαq for signaling but distinctly modulates function of the Gαi-coupled FPR2 and FFAR2, Biochemical Pharmacology 180, 114143.

4. Martina Sundqvist*, André Holdfeldt*, Shane C Wright, Thor C Møller, Esther Siaw, Karin Jennbacken, Henrik Franzyk, Michel Bouvier, Claes Dahlgren, Huamei Forsman, 2020, Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis, Biochim Biophys Acta Mol Cell Res. 867(12):118849. * These authors contributed equally.

Date of Defence: 2021-03-05
Disputation: Fredagen den 5 Mars 2021, kl 09.00, sal 2119 Hälsovetarbacken, Arvind Wallgrens backe, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Neutrophils
G-protein-coupled receptors
Formyl peptide receptor 2
Abstract: Neutrophil pattern recognition receptors belonging to the G-protein coupled receptor (GPCR) family play a role in the processes of initiation as well as resolution of inflammatory processes. Formyl peptide receptor 2 (FPR2) in neutrophils is such a receptor and plays an important role in inflammation. This thesis focuses on the molecular basis for FPR2 ligand recognition, receptor signaling and activation of neutrophils. The experimental data generate new knowledge that is related specifically ... more
ISBN: 978-91-8009-206-7 (PRINT)
978-91-8009-207-4 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin



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