Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för medicin by Title
Now showing items 285-304 of 609
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Impact of Risk Factors and Treatment in Coronary Heart Disease
(2008-12-04)Aims: The aim of the present study was to explore how risk factors and medication influence clinical presentation and mortality in coronary heart disease (CHD) and to explain how much of the decrease in CHD mortality in ... -
Impact of the GH-IGF-I axis in adults - pharmacogenetic and genetic association studies
(2013-03-28)Growth hormone (GH) is a polypeptide hormone which is secreted from the anterior pituitary in a pulsatile pattern. GH is best known by its strong effects on longitudinal growth in children, but the importance of GH is ... -
Impairment of Endothelial Thromboprotective Function by Haemodynamic and Inflammatory Stress - Implications for hypertensive disease
(2007-06-29)The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (t-PA). The endothelium synthesizes and stores t-PA and regulated release of the enzyme is an important local ... -
Implementation of gut-directed hypnotherapy for irritable bowel syndrome in clinical practice
(2012-11-14)Background: Irritable Bowel Syndrome (IBS) is characterized by recurrent abdominal pain or discomfort, related to abnormal bowel habits. This benign and common condition is in severe cases associated with bothersome GI ... -
Implementation of research and development in primary care by means of strategic communication
(2012-10-08)Background: Health and medical care today is faced with the challenge of bridging the gap between the theoretical world and the practical clinical setting. Although methods exist for implementing research results, the ... -
Importance of cardiac reserve for evaluation and prediction of cardiac function and morbidity assessed by low-dose dobutamine stress echocardiography
(2007-05-22)This thesis aimed to evaluate the cardiac reserves capacity to be used to predict treatment effects, sub clinical heart disease and to evaluate b1-adrenoceptor (AR) gene polymorphism (Ser49Gly). Studies were performed ... -
The Importance of Isoprenylation and Nf1 Deficiency in K-RAS-induced Cancer
(2009-11-10)The RAS and RHO family proteins contribute to tumorigenesis and metastasis and belong to a family of so called CAAX proteins. The membrane targeting and proper function of CAAX proteins are dependent on posttranslational ... -
The importance of long axis function -an echocardiographic study with respect to ageing, response to treatment, prediction of survival and effect of warm water immersion
(2008-10-17)Echocardiographic M-mode measurement of atrioventricular plane displacement (AVPD) and determination of annular velocity with Tissue Doppler imaging (TDI) is a reliable method to gauge ventricular long axis function for ... -
Improving Work Ability and Return to Work among Women on Long-term Sick Leave
(2014-09-19)The overall aim of this thesis was to gain new knowledge of factors and interventions that improve work ability and return to work (RTW) among women on long-term sick leave from human service organizations (HSOs). The ... -
Infectious immunity and pneumococcal vaccine responses in multiple myeloma and related disorders
(2016-09-15)Multiple myeloma (MM), Waldenstrom’s macroglobulinemia (WM), and monoclonal gammopathy of undetermined significance (MGUS) are B cell conditions associated with suppressed immune functions and susceptibility to infection. ... -
Insulin resistance and cardiovascular function - Observational, translational and interventional studies
(2016-05-26)Background: Microvascular disease is now recognized as an important driver for cardiovascular mortality and morbidity. Diabetic patients are known to suffer from this condition, leading to e.g. coronary ischemia as well ... -
Integrative network modeling of large multidimensional cancer datasets
(2015-10-07)Our ability to conduct detailed molecular investigations on tissue samples have, during the past decade, enabled the formation of databases containing measurements from thousands of cancer tumors. To harness the potential ... -
Interaction of genetic susceptibility and traffic-related air pollution in cardiovascular disease
(2015-01-28)This thesis aimed at investigating gene-environment interaction in cardiovascular disease (CVD). A study population of 618 coronary heart disease (CHD) cases (of which 192 first-time acute myocardial infarction (AMI) ... -
Intercellular communication via exosomes
(2014-01-08)Exosomes are small membrane bound vesicles between 30-100 nm in diameter of endocytic origin that are secreted into the extracellular environment by many different cell types. They play a role in intercellular communication ... -
Interleukin 15 and 17 in Staphylococcus aureus arthritis
(2011-11-09)Staphylococcus aureus–induced arthritis leads to severe joint destruction and high mortality despite antibiotic treatment. Thus, there is a need to identify new treatment targets in addition to antibiotic therapy. Interleukin ... -
Interleukin-17 in models of neutrophilic lung disease
(2006-12-20)Several acute or chronic lung disorders like adult respiratory distress syndrome, acute severe asthma, chronic obstructive pulmonary disease, chronic lung allograft rejection and cystic fibrosis, are associated with signs ... -
Intermittent claudication - studies on clinical evaluation strategies and invasive treatment efficacy
(2014-05-15)Peripheral arterial disease is a common health problem that globally affects over 200 million individuals, and intermittent claudication (IC) is the most common symptomatic presentation. The leg symptoms in IC are provoked ... -
The interplay between bile acids and gut microbiota in metabolic and hepatobiliary disease
(2023-11-21)The gut microbiota, a metabolic regulator, orchestrates the production of bioactive metabolites such as secondary bile acids. Growing evidence suggests that shifts in the gut microbiota composition are linked to metabolic ... -
Intestinal transplantation: Outcome, complications and diagnostic approach
(2021-05-27)Background: Intestinal transplantation is a potentially lifesaving procedure conducted in candidates with e.g. intestinal failure. However, a limiting factor has been the complications, which are inherent to the procedure, ... -
Intimate partner violence and its mental health and help seeking implications for young adults in Rwanda
(2015-10-13)Aim: This thesis aimed to explore the magnitude of Intimate Partner Violence (IPV), its risk factors and resulting mental health effects. A further aim was to explore the barriers to care for people suffering from mental ...