Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 15-34 of 347
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Anti-herpes simplex virus activities of sulfomannan oligosaccharide PI-88 and disulfated cyclitols
(2007-06-20)Herpes simplex virus (HSV) initiates invasion of human cells by binding to the cell surface heparan sulfate (HS) glycosaminoglycan chains. This step is mediated by the viral envelope glycoproteins gC and/or gB. Sulfated ... -
Antibiotic Resistance and Fitness of Escherichia coli in the Infantile Commensal Microbiota
(2007-05-14)Microbial resistance to antibiotics is a growing problem worldwide. Resistance develops not only in microbes which are the targets of the antibiotic treatment, but also in those belonging to the normal microbiota of the ... -
Antibiotic resistance in the environment: a contribution from metagenomic studies
(2016-05-03)Antibiotic resistance accounts for hundreds of thousands of deaths annually, and its projected increase has made the WHO recognize it as a major global health threat. In the last decade, evidence has mounted suggesting ... -
Antibiotic use and respiratory pathogens with focus on Streptococcus pneumoniae in Tanzanian children
(2023-03-30)This thesis describes the epidemiology of Streptococcus pneumoniae (pneumococci) and other respiratory pathogens after introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) and further portrays antibiotic ... -
Antiretroviral treatment of HIV-1 in Sweden with focus on virological aspects
(2021-02-11)From a clinical standpoint, there are many factors to consider when optimizing the care for people living with HIV (PLWH). With help from clinical guidelines, most obstacles can be addressed. Expanded knowledge is however ... -
Antiretroviral treatment of HIV-1 in the central nervous system
(2007-05-24)HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will ... -
Application of imaging TOF-SIMS in cell and tissue research
(2007-10-19)This thesis is aimed at extending the use of TOF-SIMS (time of flight secondary ion mass spectrometry) as an analytical tool in cell and tissue research. TOF-SIMS is a relatively new method that allows analysis of the ... -
Approaches to Enhance and Evaluate the Immunogenicity of an Oral ETEC Vaccine
(2015-11-05)Enterotoxigenic Escherichia coli (ETEC) is a major cause of childhood diarrhoea in the developing world and the most common cause of travellers’ diarrhoea. A new oral multivalent ETEC vaccine (MEV) containing killed ... -
Aspects of infection and leukemia in Rwanda
(2020-05-19)A first part of this thesis addressed the potential impact of variants of genes encoding interferon-λ4, which is a cytokine that participates in protection against pathogens at epithelial surfaces, for the resolution of ... -
The assembly of cytosolic lipid droplets and its effect on insulin sensitivity
(2007-12-21)Accumulation of neutral lipids, in particular triglycerides, in non-adipocytes is highly related to the development of insulin resistance and its consequences, type-2 diabetes and cardiovascular diseases. The accumulation ... -
Autoproteolysis accelerated by conformational strain - a novel biochemical mechanism
(2008-09-08)Natural fragmentation of polypeptide chains by autoproteolysis occurs in a number of protein families. It is a vital step in the maturation of several enzymes and in the formation of membrane-associated mucins that constitute ... -
Bacterial colonization of the neonatal bowel and ileal pouch with focus on E. coli
(2010-11-19)The colonic microbiota is a source of inflammatogenic and potentially pathogenic bacteria, but also a source of immune maturation signals to the infant. Here, we have investigated the normal colonic microbiota, with focus ... -
Biochemical studies of mitochondrial DNA maintenance and topology
(2023-04-14)Mitochondria are crucial organelles in eukaryotic cells that produce the majority of adenosine trisphosphate used by cells as an energy currency to drive metabolic processes. Due to the endosymbiotic origin of mitochondria, ... -
BiolDentification of Alk-associated signaling complexes
(2022-10-25)Anaplastic lymphoma kinase (Alk) is a receptor tyrosine kinase (RTK) of the insulin receptor family. Alterations in human ALK signaling have been implicated in multiple malignancies including pediatric neuroblastoma. In ... -
Biological functions of G-quadruplexes
(2014-11-24)G-quadruplexes are four-stranded nucleic acid structures formed by quartets of Hoogsteen base paired guanine bases. They are known to form at telomeres and other genomic sites, and are predicted to do so at a large proportion ... -
Biolubrication: Structural investigation of lubricin and its glycosylation
(2014-11-04)The sliding articular cartilage surfaces of the human diarthrodial joints are surrounded by biolubricating synovial fluid (SF), creating a perfect low friction biological biobearing structure with excellent lubrication ... -
Blood Culture Negative Endocarditis
(2006-12-05)The lethal disease infective endocarditis (IE) is caused by microorganisms that attack heart valves. Early diagnosis and identification of the causative agents are important for the choice of treatment. Optimal treatment ... -
Brain tumors in children - National population-based studies on classification, diagnostics and long-term follow-up
(2023-05-02)Although the prognosis for pediatric tumors of the central nervous system (CNS) has improved over time it is urgent to reduce mortality and improve long-term quality of life for survivors. With this aim, the first step is ... -
Broadly protective nanoparticle-based mucosal vaccine against influenza virus infection
(2018-11-12)Influenza is one of the major viral diseases affecting humans and it is responsible for three to five million cases of severe illness and about 250.000 to 500.000 deaths each year worldwide. A vaccine against pandemic ... -
Butyrophilin- and Butyrophilin-like genes and their role in epithelial cell-intraepithelial T lymphocyte cross-talk
(2016-05-04)More than 50% of our immune system is located in the gut. The intestinal epithelium, which forms an interface between the organism and the environment, harbors intraepithelial lymphocytes (IELs) that comprise a mixture of ...