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Antibiotic Resistance and Fitness of Escherichia coli in the Infantile Commensal Microbiota


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Title: Antibiotic Resistance and Fitness of Escherichia coli in the Infantile Commensal Microbiota
Authors: Karami, Nahid
E-mail: nahid.karami@microbio.gu.se
Issue Date: 14-May-2007
University: Göteborg University. Sahlgrenska Academy
Institution: Inst of Biomedicine. Dept of Medical Microbiology and Immunology
Parts of work: I. Nahid Karami, Ingegerd Adlerberth and Agnes Wold. Virulence traits, phylogenetic groups and antibiotic resistance in intestinal and urinary Escherichia coli from Swedish infants. In manuscript.

II. Nahid Karami, Ingegerd Adlerberth and Agnes Wold. Tetracycline resistance in Escherichia coli and persistence in the infantile colonic microbiota. Antimicrobial Agents and Chemotherapy, Jan. 2006, P. 156-161.

III. Nahid Karami, Charles Hannoun, Ingegerd Adlerberth and Agnes Wold. Impact of β-lactamase gene carriage on in vivo fitness of Escherichia coli in the infantile colonic microbiota. Submitted for publication.

IV. Nahid Karami, Anna Martner, Virve I. Enne, Svante Swerkersson, Ingegerd Adlerberth and Agnes Wold. Transfer of ampicillin resistance genes followed by mutational changes during natural colonization by Escherichia coli in the infantile bowel. Submitted for publication.

V. Nahid Karami, Ingegerd Adlerberth and Agnes Wold. Clonal group A (CGA) Escherichia coli involved in transfer of antibiotic resistance genes in the intestinal microbiota. In manuscript.
Links to parts of work: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16377681
Disputation: Torsdagen den 24 maj 2007 kl. 09.00, "föreläsningsalen", fl. 3, Guldhedsgatan 10A, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: ampicillin
tetracycline
in vivo fitness
persistence
gene transfer
intestinal
blaTEM Escherichia coli
Abstract: Microbial resistance to antibiotics is a growing problem worldwide. Resistance develops not only in microbes which are the targets of the antibiotic treatment, but also in those belonging to the normal microbiota of the treated host. Little is known on the ecological consequences of antibiotic resistance in commensal bacteria. Escherichia coli belongs to the normal intestinal microbiota but may also cause urinary tract infection (UTI) or septicaemia if spread from the bowel. The present thesis s... more
ISBN: 978-91-628-7178-9
URI: http://hdl.handle.net/2077/4418
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin
Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

 

 

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