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Antibiotic resistance in the environment: a contribution from metagenomic studies


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Title: Antibiotic resistance in the environment: a contribution from metagenomic studies
Authors: Bengtsson-Palme, Johan
E-mail: johan.bengtsson-palme@microbiology.se
johan.bengtsson-palme@gu.se
Issue Date: 3-May-2016
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Infectious Diseases
Parts of work: I. Bengtsson-Palme J, Hartmann M, Eriksson KM, Pal C, Thorell K, Larsson DGJ, Nilsson RH
: Metaxa2: improved identification and taxonomic classification of small and large subunit rRNA in metagenomic data. 
Molecular Ecology Resources 15, 6, 1403–1414 (2015)
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II. Bengtsson-Palme J, Larsson DGJ
: Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation
. Environment International 86, 140–149 (2016)
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III. Lundström SV, Östman M, Bengtsson-Palme J, Rutgersson C, Thoudal M, Sircar T, Blanck H, Eriksson KM, Tysklind M, Flach C-F, Larsson DGJ: Minimal selective concentrations of tetracycline in complex aquatic bacterial biofilms. Science of the Total Environment, 553, 587–595 (2016).
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IV. 
Bengtsson-Palme J, Hammarén R, Pal C, Östman M, Björlenius B, Flach C-F,
 Fick J, Kristiansson E, Tysklind M, Larsson DGJ: Elucidating selection processes for antibiotic resistance in sewage treatment plants using metagenomics. Manuscript

V. Bengtsson-Palme J, Boulund F, Fick J, Kristiansson E, Larsson DGJ: Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India. Frontiers in Microbiology, 5, 648 (2014).
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VI. Bengtsson-Palme J, Angelin M, Huss M, Kjellqvist S, Kristiansson E, Palmgren H, Larsson DGJ, Johansson A: The human gut microbiome as a transporter of antibiotic resistance genes between continents. Antimicrobial Agents and Chemotherapy, 59, 10, 6551–6560 (2015).
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VII. Bengtsson-Palme J, Larsson DGJ: Antibiotic resistance genes in the environment: prioritizing risks. Nature Reviews Microbiology, 13, 369 (2015).
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Date of Defence: 2016-05-26
Disputation: Torsdagen den 26 maj 2016, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: antibiotic resistance
metagenomics
bioinformatics
next generation sequencing
resistance selection
Abstract: Antibiotic resistance accounts for hundreds of thousands of deaths annually, and its projected increase has made the WHO recognize it as a major global health threat. In the last decade, evidence has mounted suggesting that the environment plays an important role in the progression of resistance. The external environment acts as a source of resistance genes for human pathogens, but is also an important dissemination route allowing the spread of resistant bacteria between different environments a... more
ISBN: 978-91-628-9759-8 (PDF)
978-91-628-9758-1 (print)
URI: http://hdl.handle.net/2077/41843
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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