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Aspects of infection and leukemia in Rwanda


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Title: Aspects of infection and leukemia in Rwanda
Authors: Rugwizangoga, Belson
E-mail: belson.rugwizangoga@gu.se
Issue Date: 19-May-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Infectious Diseases
Parts of work: I. Belson Rugwizangoga*, Maria E. Andersson *, Jean-Claude Kabayiza, Malin S. Nilsson, Brynja Ármannsdóttir, Johan Aurelius, Staffan Nilsson, Kristoffer Hellstrand, Magnus Lindh, Anna Martner. IFNL4 genotypes predict clearance of RNA viruses in Rwandan children with upper respiratory tract infections. Front. Cell. Infect. Microbiol. 2019;9:340. *Equal contribution
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II. Belson Rugwizangoga, Anna Rydström, Johan Aurelius, Egide Kayitare, Fabien Ntaganda, Ka-Wei Tang, Kristoffer Hellstrand, Anna Martner. Incidence, subtypes and outcome of acute myeloid leukemia in Rwanda. In Manuscript.

III. Belson Rugwizangoga, Anna Rydström, Johan Aurelius, Egide Kayitare, Fabien Ntaganda, Ka-Wei Tang, Kristoffer Hellstrand, Anna Martner. Aspects of incidence, subtypes, and outcome of acute lymphoblastic leukemia in the Rwandan population. In Manuscript.

IV. Belson Rugwizangoga*, Narcisse Niyikora*, Angèle Musabyimana*, Annie-Isabelle Izimukwiye, Johan Aurelius, Anna Martner, Aline Umubyeyi. Experience and perception of acute leukemia in Rwanda by patients and healthcare professionals. Submitted. *Equal contribution
Date of Defence: 2020-06-09
Disputation: Tisdagen den 9 juni 2020, kl. 13.00, Gösta Sandels, Medicinaregatan 9B, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: interferon-λ
respiratory infection
nucleotide polymorphism
acute leukemia
Rwanda
Epstein-Barr virus
malaria
Abstract: A first part of this thesis addressed the potential impact of variants of genes encoding interferon-λ4, which is a cytokine that participates in protection against pathogens at epithelial surfaces, for the resolution of upper respiratory tract infections in Rwandan children. In a study of 480 subjects (≤5 years old), where follow-up samples were available from 161 subjects, it was observed that IFNL4 genotypes were associated with clearance of RNA viruses from upper airways. Our results thus sug... more
ISBN: 978-91-7833-894-8 (PRINT)
978-91-7833-895-5 (PDF)
URI: http://hdl.handle.net/2077/63615
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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