Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper by Title
Now showing items 92-111 of 636
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Cartilage Tissue Engineering. A study on how to improve cartilage repair.
(2010-06-04)One of the first examples of musculoskeletal tissue engineering is autologous chondrocyte implantation (ACI).The first patient with a cartilage lesion was operated with ACI in 1987 and at that time suspension implantation ... -
CC16 in allergy and allergic inflammation
(2008-03-10)Clara cell 16-kDa (CC16) is an anti-inflammatory protein mainly produced in the lung epithelium by Clara cells. Patients with asthma have lower levels of CC16 in bronchoalveolar lavage fluid and serum compared with healthy ... -
Cell Therapy in lntervertebral Disc Degeneration
(2021-04-12)Background: Chronic low back pain (LBP) is the leading cause of disability worldwide. Intervertebral disc degeneration (IDD) is central in the pathogenesis. The injection of bone marrow-derived mesenchymal stromal cells ... -
Central and Peripheral Neuroendocrine Factors in Cancer-Associated Anorexia and Cachexia
(2015-11-26)Cancer anorexia-cachexia syndrome (CACS) develops in response to tumor-host biochemical interactions. A loss of appetite (anorexia) and increased metabolism results in a progressive wasting of adipose and skeletal muscle ... -
Central nervous modulation of pain - a clinical and experimental study
(2009-10-12)This series of studies addresses several conceptual issues in modern pain therapy related to the contemporary understanding of mechanisms and modulators involved in the pain sensation. Novel invasive therapy for severe ... -
Centralized Ovarian Cancer Care - Complications, Costs and Survival
(2022-04-19)Background: Ovarian cancer is often diagnosed at advanced stages, and its mortality is high. Surgical treatment of advanced ovarian cancer strives toward complex primary debulking surgery (PDS), aiming for complete ... -
Cerebral CT - and MRI perfusion: Techniques and clinical application in iNPH
(2015-05-18)Idiopathic normal pressure hydrocephalus (iNPH) is a disorder of the elderly, defined by slowly progressive impairment of gait and balance, cognitive decline, and incontinence. Disturbance of the cerebrospinal fluid (CSF) ... -
Cerebral palsy in western Sweden - Epidemiology and function
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Cervical and intra-amniotic markers of preterm birth and infection
(2009-03-16)Abstract Background: Preterm delivery (PTD; < 37 gestational weeks), is one of the greatest unsolved obstetrical problems worldwide. As much as 80% of the perinatal mortality and 50% of the long-term neurological handicaps ... -
Cervical and vaginal cancer - aspects on risk factors, prevention and treatment
(2021-03-26)Background: Participation in screening is associated with a major risk reduction in cervical cancer, but there is a lack of knowledge on whether the cost to the individual has an effect on the participation rate. Women ... -
Cervical cancer prevention Studies on possible improvements
(2007-12-27)Aims: The aim of this study is to target and assess possible improvements for women attending cervical cancer screening programs. Methods: In a randomized study the use of ThinPrep liquid based cytology (LBC) was tested ... -
Cervical dysplasia and cervical cancer in pregnancy: diagnosis and outcome
(2012-11-15)ABSTRACT:Cervical cancer is one of the most common types of cancer that is diagnosed during pregnancy. The primary aim in investigation of atypical cervical cytology during pregnancy is to exclude cancer so that further ... -
Changes in prevalence of asthma and allergy in Swedish school children over almost three decades and factors reducing risk of allergy
(2021-09-01)ABSTRACT Background: Asthma and allergy are one of the most common chronic diseases among children. The prevalence of allergic diseases increased dramatically during the last decades of the twentieth century. The reason ... -
Characteristics of screen-failures in prostate cancer screening
(2015-03-30)ABSTRACT Although prostate-specific antigen (PSA)-based screening has been shown to reduce prostate cancer (PC)-specific mortality with large variations in mortality reduction with different screening algorithms, the ... -
Characterization of genetic alterations in ovarian cancer associated with chemotherapy response
(2009-05-13)Ovarian cancer is the most lethal of all gynecological malignancies, and exhibit an overall fiveyear survival rate of only 48% in Sweden. The high mortality in ovarian cancer is largely due to late diagnosis and chemotherapy ... -
Characterizing and modulating the effects of ionizing radiation to the juvenile hippocampus
(2014-05-09)Survival rates after childhood cancer treatment have improved, leading to a growing population of survivors. Radiotherapy is an important tool for curing cancer in the brain. Unfortunately, radiotherapy is associated with ... -
Checkpoint inhibitor-induced adverse events in the CNS - T-cell characteristics and biomarkers
(2023-08-21)Immune checkpoint inhibitors (ICI) activate T cells to kill cancer cells by blocking inhibitory receptors PD-1 (nivolumab; nivo) or CTLA-4 (ipilimumab; ipi). Activated T cells can also attack any healthy organ, causing ... -
Chest Tomosynthesis for Detection and Surveillance of Pulmonary Pathology. Studies on Cystic Fibrosis and Solid Pulmonary Nodules
(2019-06-17)Introduction: Digital tomosynthesis (DTS) is a relatively new imaging modality in thoracic imaging. The technique is based on the equipment of conventional radiography, upgraded with a moving tube that enables separation ... -
Childhood asthma. Epidemiology, prevalence and risk factors
(2023-05-09)Background and aim: Asthma is one of the most common chronic diseases among children often resulting in medical treatment, morbidity and reduced quality of life. It is therefore important to study factors associated with ... -
Children and adolescents with Type 1 Diabetes Mellitus: family dynamics and health-related quality of life after diabetes onset
(2015-05-21)ABSTRACT Aim: The main aim of this thesis was to explore different aspects of family dynamics and health- related quality of life (HRQOL) after the onset of T1DM in children and adolescents. A second aim was to ...