Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper by Title
Now showing items 317-336 of 636
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Magnetic Resonance Imaging as a Screening Tool for Prostate Cancer
(2021-04-20)The overall aim of this thesis was to explore the role of Magnetic resonance imaging (MRI) of the prostate as an adjunct to the prostate-specific antigen (PSA)-test in screening for prostate cancer (PCa), focusing on the ... -
Maintaining quality of life after prostate cancer diagnosis
(2011-09-30)Knowledge of real-life factors that are associated with men’s self-assessed quality of life after prostate-cancer diagnosis could improve the support from health-care professionals in maintaining the men’s quality of life. ... -
Management of late term pregnancy
(2021-02-17)Background: The optimal time point to intervene and induce labour in women with a low-risk pregnancy, in order to decrease perinatal adverse outcome, is up for debate. Some advocate for induction of labour (IOL) at 41 ... -
Markers and mechanisms of abnormal neurovascular development in the preterm infant
(2023-01-18)Background: The extremely preterm infant is at risk of lifelong neurodevelopmental impairments due to brain injuries or abnormal neurovascular development. Mechanisms are largely unknown and biomarkers for adverse outcomes ... -
Maternal and placental inflammatory biomarkers in spontaneous preterm delivery - Predictive ability, stability and neonatal associations
(2017-03-28)Preterm delivery (PTD), spontaneous or iatrogenic, causes short- and long-term morbidity and underlies almost 75% of neonatal deaths. The prevalence in the Nordic countries is about 6% but it differs among countries. In ... -
Mean systemic filling pressure - from Guyton to the ICU, and back again
(2019-02-01)Introduction: Mean systemic filling pressure (MSFP) is the equilibrated vascular pressure at zero flow. Venous return (VR) driving pressure (VRdP) is the difference between MSFP and right atrial pressure (RAP). In clinical ... -
Measurement of outcome in lumbar spine surgery
(2020-04-02)BACKGROUND. The purpose of elective lumbar spine surgery is mainly to reduce pain and to improve physical function and quality of life. The quality and results of the interventions are monitored in the Swedish spine register, ... -
Measurement of T1 relaxation time in lungs - Preclinical and clinical MRI applications to COPD
(2015-09-16)Monitoring of regional lung function in clinical trials of chronic obstructive pulmonary disease (COPD) requires alternative endpoints beyond global pulmonary function tests (PFTs), which is the most common approach for ... -
Mechanisms of intestinal tumor initiation and progression in ApcMin mouse model of colorectal cancer
(2018-03-02)Colorectal cancer (CRC) is a cancer that occurs in the colon or rectum and is one of the most common cancer forms and a leading cause of cancer death in the Western world. The majority of CRCs are caused by inherited or ... -
Mechanisms of Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia
(2009-11-26)Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects preterm infants. Increased levels of inflammatory mediators in the amniotic fluid and in the lungs of preterm infants are associated with the development ... -
Mechanisms of Osseointegration: Experimental Studies on Early Cellular and Molecular Events in vivo
(2010-06-14)The early cellular and molecular activities determining the early tissue response and bone formation at bone/implant interface are not fully understood. The general aim of the current thesis was to develop a model for ... -
Melanoma surgery in the era of modern immunotherapy
(2024-01-30)Recent advances in immuno-oncology have led to a paradigm shift in the treatment of advanced cutaneous melanoma. The aim of this thesis is to investigate the role of surgery in the management of melanoma in this modern era ... -
Mental adjustment and Health-related: Quality of Life In laryngeal cancer patients Quantitative and Qualitative approaches
(2010-08-30)The overall aim of this thesis was to investigate mental adjustment and HRQL in patients treated for laryngeal cancer. Specific aims were to evaluate if either VAS or Likert response options was more suitable when assessing ... -
Mesh-Based Immediate Breast Reconstruction. Complicantions and long-term results
(2019-01-09)There are few high-quality studies evaluating use of meshes in implant-based immediate breast reconstruction (IBR). This thesis analyzed current evidence of matrices and compared outcomes from the use of biological or ... -
Metabolic responsiveness to growth hormone in children
(2012-03-13)Metabolic effects of growth hormone (GH) therapy in short children have not been clearly established owing to the previous lack of controlled trials studying the metabolic outcome in response to different GH doses despite ... -
Methodological considerations in epidemiological studies in perinatal medicine
(2021-05-05)This thesis is based on two projects, each consisting of two papers. In these two projects we investigated factors affecting the variability in gestational duration, and associations between maternal diet and neonatal ... -
Methods in Diagnosing Chronic Anterior Compartment Syndrome. A clinical study in patients with exercise induced leg pain
(2015-04-27)Chronic anterior compartment syndrome (CACS) is a painful condition within one or more muscle compartment(s) in the lower leg. It impedes blood flow and muscular function due to elevated intramuscular pressure. The ... -
Methotrexate and Risk of Cutaneous Melanoma
(2019-09-06)Methotrexate (MTX) is an anti-inflammatory and immunosuppressive drug commonly used to treat psoriasis, psoriatic arthritis and rheumatoid arthritis. Cutaneous malignant melanoma (CMM) is a common and dangerous type ... -
Methylome and Transcriptome Profiling of Hepatocytes Derived from Human Pluripotent Stem Cells
(2018-02-22)Six hundred million people suffering from liver diseases worldwide of which the lethality is two million. Freshly isolated hepatocytes from the liver have been used for transplantation purposes and are extensively used to ... -
Metopic synostosis - surgical results and perinatal aspects
(2022-04-27)Metopic synostosis (MS) is the second most common type of craniosynostosis (CS). This thesis aimed to evaluate surgical results in children operated for MS, their perinatal outcomes and potential etiological risk ...