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Cell Therapy in lntervertebral Disc Degeneration

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Title: Cell Therapy in lntervertebral Disc Degeneration
Authors: Papadimitriou, Nikolaos
Issue Date: 12-Apr-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Orthopaedics
Parts of work: I. Papadimitriou N, Thorfve A, Brantsing C, Junevik K, Baranto A and Barreto Henriksson H (2014). "Cell viability and chondrogenic differentiation capability of human mesenchymal stem cells after iron labeling with iron sucrose." Stem Cells Dev 23(21): 2568-2580.

II. Papadimitriou N, Li S and Barreto Henriksson H (2015). "Iron sucrose-labeled human mesenchymal stem cells: in vitro multilineage capability and in vivo traceability in a lapine xenotransplantation model." Stem Cells Dev 24(20): 2403-2412.

III. Papadimitriou N, Hebelka H, Hingert D, Baranto A, Barreto Henriksson H, Lindahl A, Brisby H. “Intra discal injection of iron-labeled autologous mesenchymal stromal cells in patients with chronic low back pain. A feasibility study with 2 years follow up.” Manuscript.

IV. Papadimitriou N, Hebelka H, Waldenberg C, Lagerstrand K, Brisby H. “Longitudinal MRI evaluation of disc and adjacent tissues up to 2 years after intervertebral disc injection of autologous mesenchymal stromal cells.” Manuscript.

V. Henriksson H B,Papadimitriou N, Hingert D, Baranto A, Lindahl A and Brisby H (2019). "The traceability of mesenchymal stromal cells after injection into degenerated discs in patients with low back pain." Stem Cells Dev 28(17): 1203-12.

Date of Defence: 2021-05-07
Disputation: Fredagen den 7 maj 2021, kl 09.00, R-aulan, Sahlgrenska Universitetssjukhuset, Mölndal
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Low back pain
Mesenchymal stromal cell
Intervertebral disc
Intervertebral disc degeneration
Degenerative disc disease
Cell therapy
Abstract: Background: Chronic low back pain (LBP) is the leading cause of disability worldwide. Intervertebral disc degeneration (IDD) is central in the pathogenesis. The injection of bone marrow-derived mesenchymal stromal cells (BM-MSCs) into degenerate intervertebral discs (IVDs) has been proposed as an alternative therapy. The aims of these studies were to investigate the iron labeling of human BM-MSCs in vitro and in an animal model, to assess the feasibility and efficacy of the intradiscal injection... more
ISBN: 978-91-8009-280-7 (PRINT)
978-91-8009-281-4 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper



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