Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper
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Child predisposition to attention-deficit/hyperactivity disorder, autism spectrum disorder, and obesity: Predictive variables in the first year of life and growth patterns in a population-based context
(2025-05-23)The prevalence of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) has increased in the last decades, together with childhood obesity. These conditions often co-occur and may share ... -
Mannitol - a new-old marker for measuring glomerular filtration rate
(2025-05-22)Mannitol – a new-old marker for measuring glomerular filtration rate ABSTRACT Acute kidney injury is a serious complication in critically ill patients, associated with increased morbidity and mortality. Furthermore, ... -
Diffusion MRI for tumor microstructure imaging using VERDICT modeling
(2025-05-20)VERDICT is a method which uses a mathematical model that provides estimates of microstructural tumor tissue parameters based on diffusion-weighted MRI data. It is a promising imaging method for non-invasive in vivo evaluation ... -
Becoming an Anaesthetist – Making the Implicit Explicit in Specialty Training
(2025-05-20)This thesis explores the qualitatively different ways anaesthetists understand learning—both formal and informal—within postgraduate anaesthesia education. Using a phenomenographic approach, it investigates how anaesthetists ... -
Image-Based Dosimetry in Targeted Radionuclide Therapy with Terbium-161: From Technical Foundations to Clinical Application
(2025-05-15)This work explores SPECT/CT-based quantification of the novel therapeutic radionuclide terbium-161 (161Tb). The interest in 161Tb stems from its substantial emission of low-energy conversion and Auger electrons, hypothesized ... -
Simulated Daylight Photodynamic Therapy for Superficial Basal Cell Carcinoma and Actinic Keratoses
(2025-05-13)The overall aim of this thesis was to evaluate simulated daylight photodynamic therapy (SDL-PDT) for the treatment of actinic keratoses (AKs) and superficial basal cell carcinoma (sBCC). The included studies assessed this ... -
From extra-skeletal bone growth to re-osseointegration: Osteoinduction and mechanical disruption in bone repair
(2025-05-13)The effort to preserve the integrity and function of the skeletal system has driven scientific innovation for centuries. Clinical challenges—such as tooth loss, joint failure, limb amputation, and large bone voids caused ... -
Enhancing the Management of High-Risk Basal Cell Carcinoma
(2025-05-13)Basal cell carcinoma (BCC) is the most common skin cancer, with over 71,000 new cases in Sweden in 2023. High-risk facial BCCs are most appropriately treated with Mohs micrographic surgery (MMS), which is considered the ... -
Allergic Rhinitis in Childhood and Young Adulthood: Epidemiology, Prevalence and Risk Factors
(2025-05-08)Background and Aim: Allergic rhinitis (AR) is a common chronic condition among young people. This thesis examines the prevalence, risk, and protective factors of AR in 12-year-olds. It also compares questionnaire-derived ... -
Personalized analysis of circulating tumor DNA in childhood malignancies
(2025-05-08)Circulating tumor DNA (ctDNA) analysis has emerged as a powerful technique for precision medicine in pediatric oncology. ctDNA refers to small fragments of tumor-derived genetic material that are released into the ... -
Utmaningar och förbättringsmöjligheter för MR-faskontrast vid diagnostik av kronisk aortainsufficiens
(2025-04-29)Aortic valve regurgitation (AR) occurs when the valve fails to close properly, allowing blood to flow back into the left ventricle during diastole. This puts extra strain on the heart and, over time, can lead to damage ... -
Monte Carlo and machine learning approach to in-vivo transmission dosimetry for dynamic radiation treatments
(2025-04-17)In this thesis the main aim was to improve patient-specific quality assurance (QA) in external beam radiotherapy for dynamic techniques such as intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy ... -
The Fallopian tube - to be or not be removed. Opportunistic salpingectomy at benign hysterectomi
(2025-04-15)Background: Opportunistic salpingectomy (OS) is increasingly common during benign hysterectomy as a preventive measure for epithelial ovarian cancer (EOC). However, there is limited research on the procedure's impact on ... -
Clinical management of medical abortion beyond 12 gestational weeks
(2025-04-14)Clinical Management of Medical Abortion Beyond 12 Gestational Weeks Johanna Rydelius Department of Obstetrics and Gynecology, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg Gothenburg, ... -
Long-term effects of radiotherapy in head and neck cancer: Trismus and patient perspectives
(2025-04-14)This thesis aims to increase knowledge about patients’ long-term symptoms related to mouth opening, pain perception, and health-related quality of life (HRQL) after radiotherapy for head and neck cancer (HNC). Furthermore, ... -
Myringoplasty. Studies on surgical and patient-related outcomes
(2025-03-27)A tympanic membrane (TM) perforation can lead to hearing loss and recurrent ear infections. Myringoplasty, a surgical procedure aiming to heal the perforation, is performed on approximately 800 individuals annually in ... -
Evaluations of Monte Carlo and AI Techniques for SPECT Reconstruction
(2025-03-21)Molecular radiotherapy is an effective treatment that uses radionuclides bound to molecules that selectively target specific tumor types. SPECT imaging in molecular radiotherapy enables dosimetry, allowing for the estimation ... -
Effects of contrast media on renaI and thyroid function - and the impact of thyroid nodules
(2025-03-21)The risk of renal damage by iodine contrast media (ICM) has long been discussed but there is still controversy about whether contrast-induced acute kidney injury (CI-AKI) exists. ICM-induced thyroid dysfunction is a less ... -
Patient characteristics and their impact on recovery after acute Achilles tendon rupture
(2025-03-17)The incidence of acute Achilles tendon rupture has increased in the Swedish population. The median age at injury onset is roughly 50 years, with a male-to-female ratio of approximately 4:1. Acute Achilles tendon rupture ... -
Artificial intelligence-based organ and tumour segmentation in prostate cancer patients. Studies on PET/CT and pre-treatment CT scans.
(2025-03-11)Aim: This thesis aimed to evaluate the prognostic and clinical significance of artificial intelligence (AI)-based segmentation and quantification of the prostate, the prostate tumour and the surrounding risk organs (OARs), ...
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