Institute of Clinical Sciences / Institutionen för kliniska vetenskaper
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Quality of life and long-term side effects after anal cancer treatment
(2024-02-28)Anal cancer is a rare type of cancer with approximately two hundred new cases in Sweden per year. Treatment usually consists of a combination of radiotherapy and chemotherapy. Overall prognosis is good but about 10% of ... -
Melanoma surgery in the era of modern immunotherapy
(2024-01-30)Recent advances in immuno-oncology have led to a paradigm shift in the treatment of advanced cutaneous melanoma. The aim of this thesis is to investigate the role of surgery in the management of melanoma in this modern era ... -
Psychosocial Aspects of Dravet Syndrome
(2024-01-15)Dravet syndrome (DS) is a developmental and epileptic encephalopathy, associated with significant neurodevelopmental comorbidity. The aims of this population-based study were to describe the epidemiology, genetics, mortality, ... -
Uterine Tissue Engineering: Translational approaches using animal models
(2023-12-14)Recent advancements, such as uterus transplantation (UTx), have led to groundbreaking solutions for complete uterine dysfunction. Yet, there are inherent risks and limitations, including challenges of sourcing compatible ... -
Femoral shaft fractures in children and adolescents; stability, residual deformity and recovery of physical function
(2023-12-14)Femoral shaft fracture is the most common injury requiring hospital admission among children. The limited number of studies makes it challenging to provide accurate prognosis for recovery after femoral shaft fractures in ... -
lncidence of Colorectal Cancer and Comparisons of Outcomes after Minimally Invasive and Open Surgery
(2023-12-07)Aim: Surgery remains the mainstay of treatment for colorectal cancer. The aim of this thesis was to determine the overall incidence of colorectal cancer in Sweden over time and to evaluate surgical treatment comparing ... -
lmprovement of 177Lu-octreotate treatment of small-intestine neuroendocrine tumors by hyperfractionation
(2023-11-24)Neuroendocrine tumor incidence is steadily rising, and the late diagnosis often results in metastatic disease and current treatments mostly prolong life and in-crease quality of life without increasing cure rate. ... -
Acute Achilles tendon rupture: The impact of physiological and psychological factors on function and return to activity
(2023-11-17)Unfortunately, there is no guarantee of a full return to physical activity after an Achilles tendon rupture. About 20% of those who sustain the injury do not return to their previous level of physical activity. Although ... -
Risk Factors for Diabetic Ketoacidosis in Children
(2023-11-10)Background: Diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes. It is preventable if timely administration of sufficient amounts of insulin is initiated. A large proportion of children are ... -
Ultrasound and molecular biomarkers for prediction of preterm delivery in different risk groups of singleton pregnancies
(2023-11-06)Ultrasound and molecular biomarkers for prediction of preterm delivery in women with a singleton pregnancy Tove Wikström Department of Obstetrics and Gynecology, Institute of Clinical Sciences Sahlgrenska Academy, ... -
Morbidity and mortality following standardised perioperative management of patients operated with acute abdominal surgery in a high-risk emergency setting
(2023-11-06)Patients suffering from acute pathology in the abdomen is common throughout the world and surgical intervention can often be necessary. Those who are most seriously ill need an acute management with major abdominal surgery, ... -
Diffusion MRI: Aspects of Reproducibility and Novel Segmented 2D and 3D Approaches for Higher Resolution and Geometric Fidelity
(2023-11-06)Diffusion-weighted imaging (DWI) is a very useful tool for non-invasive imaging and clinical investigation of the human body. It provides data of the water diffusion process. Applied to biological tissues in a clinical ... -
Advancements in DSC and BOLD perfusion imaging: Acquisition, analysis and clinical application
(2023-10-31)This thesis is focused on perfusion MRI techniques and topics related to image acquisition, analysis and clinical applications. The first half of the thesis is focused on dynamic susceptibility contrast (DSC) MRI, a technique ... -
Obstetric Emergency Triage - A new mindset in obstetric emergency care in Sweden
(2023-10-30)Introduction Obstetric emergency triage, facilitating prioritization according to urgency of obstetric patients seeking emergency care, is a relatively new form of triage. Adaptations to physiological changes during ... -
Biodegradable magnesium implants, immunomodulation, and tissue repair/regeneration
(2023-10-26)The century-old paradigm of holding fractures with a metallic implant to enable bone repair, known as osteosynthesis, is still used today without alteration. Patients are increasingly being treated with metallic implants ... -
Basal cell carcinoma: real-life burden on healthcare and simplified destructive treatments
(2023-10-18)Basal cell carcinoma (BCC) is the most common cancer in humans. With steadily increasing incidence rates, there is a constant need to evaluate current diagnostic methods and treatment alternatives to achieve effective care ... -
Obesity and IVF outcome. The hope of improvements through weight reduction
(2023-09-20)Background: Female obesity is associated with decreased live birth rate (LBR) after in vitro fertilization (IVF) and adverse maternal and perinatal outcomes are increased in obese women compared to normal weight women after ... -
Short- and long-term outcomes after aneurysmal subarachnoid hemorrhage
(2023-09-15)Aneurysmal subarachnoid hemorrhage (aSAH) is a sudden and devastating event with significant morbidity and mortality. The development of delayed cerebral ischemia (DCI) is a major contributor to the observed high morbidity. ... -
Left ventricular dysfunction in critically ill patients
(2023-09-08)ABSTRACT Background: Cardiac dysfunction is common in Intensive Care Unit (ICU) patients and can contribute to multiorgan failure and death. Despite this, few studies have been performed on pathogenies, prevalence, ... -
How does the technical status of medical ultrasound equipment affect image quality? Studies based on human observer experiments and a novel method for automatic detection of defective transducers
(2023-08-25)Ultrasound as an imaging modality has a fundamental role in modern healthcare. The equipment, especially transducers, is fragile and handled daily, and transducers are known to sometimes become defective. The overall ...