Institute of Clinical Sciences / Institutionen för kliniska vetenskaper
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Early detection of critical congenital heart defects in Sweden - with a focus on coarctation of the aorta
(2023-05-30)Introduction: Despite the implementation of prenatal and neonatal screening, newborn infants with critical congenital heart defects (CCHD) remain at risk of being discharged undiagnosed, particularly newborns with coarcation ... -
Distal femur fracture in the elderly patient
(2023-05-25)Studies on the epidemiology of distal femur fractures show a vast increase in low-energy trauma-associated fractures in older ages. Age-related changes in bones lead to loss of bone matrix and increased porosity, which ... -
Treatment of Head and Neck Cancer, Effects on Health-Related Quality of Life and Nutrition
(2023-05-24)The aim of this thesis was to explore the impact of treatment on health-related quality of life (HRQoL), fatigue and nutrition in head and neck cancer (HNC) patients. The tumour locations often induce problems with swallowing ... -
Necrotizing enterocolitis - growth, bone health and intestinal microbiota during childhood
(2023-05-24)Necrotizing enterocolitis (NEC) is a dreaded gastrointestinal disease primarily affecting infants born preterm. Despite extensive research, NEC is still one of the most devastating diseases in neonatal intensive care. ... -
On the diagnosis and treatment of intraepidermal carcinoma
(2023-05-24)Abstract: Intraepidermal carcinoma (IEC), also known as Bowen disease (BD) or squamous cell carcinoma (SCC) in situ, is a precursor to SCC. The incidence of IEC is increasing rapidly in fair-skinned populations with a ... -
The proteasome as a target for cancer therapy
(2023-05-23)The main objective of this PhD thesis was to evaluate the significance of proteasome genes as prognostic markers for different cancer types and identify specific cancer forms that respond to proteasome inhibition. The ... -
Small-scale dosimetry methods for normal tissues after radioembolization and peptide receptor radiotherapies; a focus on the liver parenchyma and the bane marrow
(2023-05-23)Radionuclide therapies are increasingly used in cancer treatments as they have been proven to be both effective and safe. As biodistributions and uptake vary widely between patients, a standardized approach is bound to ... -
Multimodal and multiscale characterization of bone and bone interfaces in health and disease
(2023-05-16)Seeing is believing. Our understanding of phenomena often involves their direct observation. However, bone architecture is challenging to visualize given its multi-level hierarchical organization. In this thesis, bone and ... -
On massive weight loss and body contour
(2023-05-16)Abstract Background/Aims: Bariatric surgery is an effective treatment for severe obesity. However, massive weight loss is associated with adverse effects, such as excess skin. The overall aim of this thesis was to investigate ... -
Bowel Habits and Functional Constipation - A Longitudinal Birth Cohort Study of Children Born in Gothenburg
(2023-05-15)Background: Parents often visit health facilities with concerns regarding their child’s bowel function. Data on bowel habits from healthy children is important in establishing what is normal and what is not. Functional ... -
Childhood asthma. Epidemiology, prevalence and risk factors
(2023-05-09)Background and aim: Asthma is one of the most common chronic diseases among children often resulting in medical treatment, morbidity and reduced quality of life. It is therefore important to study factors associated with ... -
Rhinosinusitis beyond the upper airways. Epidemiological aspects.
(2023-05-09)Rhinosinusitis (RS) is a prevalent, multi-factorial disease, including several subgroups of disease with different characteristics and pathophysiology. RS symptoms for more than 12 weeks are defined as chronic rhinosinusitis ... -
Long-term follow-up after intensive care: Development of an ICU-specific questionnaire
(2023-05-03)Background: With improved results in intensive care comes a shift in focus – from survival to survivorship. Studies show that ICU survivorship includes effects on, for example, mental and physical health, cognition, ADL, ... -
The role of plant-food components in pelvic-organ cancer survivors - From feasibility to effects in randomized controlled dietary interventions
(2023-04-27)Background: The number of people who are surviving cancer is steadily growing. Dietary components have a potential role in preventing the side effects of treatment for pelvic-organ cancer, as well as tumor recurrence ... -
Development of new MRl-based analysis methods for improved diagnosis of low back pain patients
(2023-04-27)BACKGROUND Low back pain (LBP) is the leading cause of disability worldwide, where three of four individuals experience back pain at some point in their lives. The pathophysiological background of LBP is probably ... -
Förbättrad radionuklidterapi av neuroblastom
(2023-04-26)Today, about half of the children diagnosed with high-risk neuroblastoma (HR-NB) survive due to considerable treatment improvements during the last decades. However, there is still much to be done for the other half who ... -
Renal injury in liver transplantation clinical and mechanistic studies
(2023-04-19)ABSTRACT Background: Renal injury in liver transplantation (LT) is common and presents both as early and late insufficiency. These conditions are interconnected and have substantial impact on the long-term outcome. Multiple ... -
Thymus dysfunction in the 22q11 deletion syndrome
(2023-04-12)Introduction: The 22q11.2 deletion syndrome (22q11DS) is associated with heterogeneous clinical findings, including T-cell immunodeficiency resulting from thymus hypoplasia. Newborn screening programs based on the ... -
Treatment failure in pediatric acute myeloid leukemia: factors associated with frequency and outcome of resistant disease and relapse.
(2023-03-30)Although the prognosis for childhood acute myeloid leukemia (AML) has improved over the last decades to a survival of over 70%, still 30-40 % relapse and 5-10% experience resistant disease with poor prognosis. The aim of ... -
Chronic Achilles tendon rupture - surgical reconstruction and post-operative outcomes
(2023-03-28)When the treatment of Achilles tendon ruptures is delayed by more than 4 weeks, the rupture is classified as chronic. This thesis aims to examine the postoperative outcome of chronic Achilles tendon ruptures treated ...
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