Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper by Title
Now showing items 466-485 of 636
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Prostate Cancer Screening - Aspects of Overdiagnosis
(2014-11-28)The overall aim of this thesis is to explore aspects of overdiagnosis, i.e. the diagnosis of a tumor that in the absence of screening would never have been diagnosed, in prostate cancer (PC) screening. The four papers in ... -
Prostate cancer screening with PSA - A study of potential negative consequences
(2010-11-19)Aims: The Göteborg randomized population-based prostate cancer screening trial is a prospective study evaluating the efficacy of prostate-specific antigen (PSA)-based screening and its effect on prostate cancer mortality. ... -
Prostate Cancer Screening: Outcomes and Risk Prediction
(2018-12-12)Prostate Cancer Screening: Outcomes and Risk Prediction Maria Frånlund, MD Department of Urology, Institute of Clinical Sciences Sahlgrenska Academy at University of Gothenburg, Sweden ABSTRACT The Göteborg Randomized ... -
Prostate Diseases and the Metabolic Syndrome
(2015-04-23)ABSTRACT The overall aim of this thesis was to explore the association between the components of the metabolic syndrome (MetS), including vitamin D, and lower urinary tract symptoms (LUTS). The focus was on the relationship ... -
The proteasome as a target for cancer therapy
(2023-05-23)The main objective of this PhD thesis was to evaluate the significance of proteasome genes as prognostic markers for different cancer types and identify specific cancer forms that respond to proteasome inhibition. The ... -
Proximal and distal humeral fractures. Outcome of primary arthroplasty
(2022-05-19)This thesis deals with both proximal humeral fractures and elbow injuries, especially distal humeral fractures. The main focus is difficult fractures in the elderly. Few randomized controlled trials (RCTs) are available. ... -
Psychosocial Aspects of Dravet Syndrome
(2024-01-15)Dravet syndrome (DS) is a developmental and epileptic encephalopathy, associated with significant neurodevelopmental comorbidity. The aims of this population-based study were to describe the epidemiology, genetics, mortality, ... -
Psychosocial support needs after a breast cancer diagnosis
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Public Health Aspects of Preterm Birth. Studies using Scandinavian population-based data
(2008-05-15)Background: Preterm birth is an unresolved serious global health problem. Research must be multi-disciplinary, with assessment of risk factors and causative agents at many levels of observation. Such an important level is ... -
Pulmonary atresia with intact ventricular septum epidemiology and outcome in children born in Sweden 1980-1999
(2008-04-22)Aims: To describe children born with pulmonary atresia with intact ventricular septum (PA-IVS) in Sweden between 1980 and 1999, the incidence and outcome of PA-IVS, to examine cardio-pulmonary outcomes in survivors and to ... -
Pulmonary ventilation and perfusion assessed by electrical impedance tomography - Experimental studies in pigs
(2009-08-28)Pulmonary ventilation and perfusion and ventilation/perfusion (V/Q) matching determine gas exchange in every lung unit in the healthy state and in the pathologically altered lung. Mismatch of V and Q lead to hypoxaemia and ... -
Pulse oximetry: Evaluation of a potential tool for early detection of critical congenital heart disease
(2009-03-31)Background: About one third of newborns with life-threatening congenital heart disease leave newborn nurseries without the problem being recognized, and risk death or serious damage from circulatory collapse. The main aim ... -
Pulse-Synchronous Intramuscular Pressure Oscillations
(2016-01-12)Background Intramuscular pressure (IMP) is measured in studies of tissue nutrition and in the diagnosis of compartment syndromes. Patients with compartment syndromes have an elevated IMP due to increased volume in a ... -
Quality of life and long-term side effects after anal cancer treatment
(2024-02-28)Anal cancer is a rare type of cancer with approximately two hundred new cases in Sweden per year. Treatment usually consists of a combination of radiotherapy and chemotherapy. Overall prognosis is good but about 10% of ... -
Quality of life and morbidity in patients with rectal cancer
(2016-10-24)Aim: The aim of this thesis was to investigate patient-reported and clinical outcome in patients with rectal cancer with specific focus on treatment-associated morbidity and quality of life. Method: Three clinical studies ... -
Quality of life and psychological reactions in women on first line chemotherapy for metastatic breast cancer - Correlations to tumour response and predictive factors.
(2011-03-25)Background: Health-related quality of life (HRQoL) is an important endpoint in clinical trials and as an aspect that must be considered in the treatment of patients with metastatic breast cancer. Treatment efficacy and ... -
Radiation-induced dysphagia in head and neck cancer - risk structures and methodological aspects
(2019-08-19)Background/Aims: Swallowing difficulties are common after radiation therapy (RT) in head and neck cancer (HNC). The overall aim of this thesis was to address radiation-induced late dysphagia with regard to investigating ... -
Radiobiological effects of alpha-particles from Astatine-211: From DNA damage to cell death
(2011-05-26)ABSTRACT In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an -particle emitting radionuclide, promising ... -
Radiobiological effects of the thyroid gland - transcriptomic and proteomic responses to 131l and 211At exposure
(2015-04-08)Radionuclides are widely used in medicine. 131I is one of the most employed radionuclides and is administered to patients either bound to tumor targeting molecules or as halide to target the thyroid or thyroid cancer. 211At ... -
Radiological evaluation of esophageal function in dysphagia with special emphasis on achalasia
(2008-10-03)In idiopathic achalasia, degeneration of the inhibitory innervation of the esophageal smooth muscle results in absence of primary peristalsis and in incomplete relaxation of the lower esophageal sphincter (LES). All ...