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Prostate Cancer Screening - Aspects of Overdiagnosis

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Title: Prostate Cancer Screening - Aspects of Overdiagnosis
Authors: Arnsrud Godtman, Rebecka
Issue Date: 28-Nov-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Urology
Parts of work: I: Godtman R, Holmberg E, Stranne J, Hugosson J. High accuracy of Swedish death certificates in men participating in screening for prostate cancer: a comparative study of official death certificates with a cause of death committee using a standardized algorithm. Scand J Urol Nephrol. 2011;45(4):226-32.

II: Arnsrud Godtman R, Holmberg E, Khatami A, Stranne J, Hugosson J. Outcome following active surveillance of men with screen-detected prostate cancer. Results from the Göteborg randomised population-based prostate cancer screening trial” Eur Urol. 2013;63(1):101-7.

III: Arnsrud Godtman R, Holmberg E, Lilja H, Stranne J, Hugosson J. Opportunistic testing versus organized prostate-specific antigen screening, outcome after 18 years in the Göteborg Randomised Population-Based Prostate Cancer Screening Trial. Submitted

IV: Anrsrud Godtman R, Carlsson S, Holmberg E, Stranne J, Hugosson J. Age at termination of screening – the most important risk factor for (over) diagnosis in screening for prostate cancer. Results from the Göteborg Randomised Population-based Prostate Cancer Screening Trial. In manuscript.
Date of Defence: 2014-12-10
Disputation: Onsdagen den 10 december 2014, kl 13.00, Hjärtats aula, Vita stråket 12, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: active surveillance
cause of death
prostate cancer
prostate-specific antigen
risk factors
screening interval
Abstract: The overall aim of this thesis is to explore aspects of overdiagnosis, i.e. the diagnosis of a tumor that in the absence of screening would never have been diagnosed, in prostate cancer (PC) screening. The four papers in this thesis all emerge from the Göteborg randomized population-based PC screening trial, in which 10,000 men were invited to biennial prostate-specific antigen (PSA)-screening between 1995 and 2014 and 10,000 non-invited constituted a control group. In paper I, the accuracy of c... more
ISBN: 978-91-628-9224-1 (tryckt version)
978-91-628-9251-7 (pdf)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper



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