Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper by Title
Now showing items 329-348 of 636
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Mental adjustment and Health-related: Quality of Life In laryngeal cancer patients Quantitative and Qualitative approaches
(2010-08-30)The overall aim of this thesis was to investigate mental adjustment and HRQL in patients treated for laryngeal cancer. Specific aims were to evaluate if either VAS or Likert response options was more suitable when assessing ... -
Mesh-Based Immediate Breast Reconstruction. Complicantions and long-term results
(2019-01-09)There are few high-quality studies evaluating use of meshes in implant-based immediate breast reconstruction (IBR). This thesis analyzed current evidence of matrices and compared outcomes from the use of biological or ... -
Metabolic responsiveness to growth hormone in children
(2012-03-13)Metabolic effects of growth hormone (GH) therapy in short children have not been clearly established owing to the previous lack of controlled trials studying the metabolic outcome in response to different GH doses despite ... -
Methodological considerations in epidemiological studies in perinatal medicine
(2021-05-05)This thesis is based on two projects, each consisting of two papers. In these two projects we investigated factors affecting the variability in gestational duration, and associations between maternal diet and neonatal ... -
Methods in Diagnosing Chronic Anterior Compartment Syndrome. A clinical study in patients with exercise induced leg pain
(2015-04-27)Chronic anterior compartment syndrome (CACS) is a painful condition within one or more muscle compartment(s) in the lower leg. It impedes blood flow and muscular function due to elevated intramuscular pressure. The ... -
Methotrexate and Risk of Cutaneous Melanoma
(2019-09-06)Methotrexate (MTX) is an anti-inflammatory and immunosuppressive drug commonly used to treat psoriasis, psoriatic arthritis and rheumatoid arthritis. Cutaneous malignant melanoma (CMM) is a common and dangerous type ... -
Methylome and Transcriptome Profiling of Hepatocytes Derived from Human Pluripotent Stem Cells
(2018-02-22)Six hundred million people suffering from liver diseases worldwide of which the lethality is two million. Freshly isolated hepatocytes from the liver have been used for transplantation purposes and are extensively used to ... -
Metopic synostosis - surgical results and perinatal aspects
(2022-04-27)Metopic synostosis (MS) is the second most common type of craniosynostosis (CS). This thesis aimed to evaluate surgical results in children operated for MS, their perinatal outcomes and potential etiological risk ... -
Microcirculation in tissue repair - from microsurgery to 3D bioprinting
(2021-03-03)Microsurgical reconstruction is challenged by two main shortcomings: Perfusion Related Complication (PRC) and donor site morbidity. In the first 3 studies of this thesis, we aimed to provide solutions to PRC-problems, ... -
Microdosimetry of radiohalogens in thyroid models
(2014-02-10)The radiohalogens 123I, 124I, 125I, 131I, and 211At are routinely used or proposed for diagnostic and therapeutic purposes. The different characteristics and application areas of these radioiodine isotopes, together with ... -
Midkine in Advanced Prostate Cancer - Biological Impact and Biomarker Potential
(2017-12-15)Prostate cancer (PC) is generally an androgen-driven disease, why androgen deprivation therapy (ADT) is the cornerstone for treatment of advanced and metastatic hormone-naïve PC (HNPC). ADT generally offers a good initial ... -
Migration of Natural Killer Cells. Matrix interaction, locomotion and regulation of matrix metalloproteinases (MMPs) by IL-2 and chemokines
(2009-08-28)Activated natural killer (NK) cells are effective anti-tumour cells. In order to reach target cells in a tumour mass they need to migrate in the extravascular space. The process of tumour localisation begins when the NK ... -
Mild primary hyperparathyroidism - Long-term effects of parathyroidectomy versus observation - with emphasis on skeletal outcomes
(2022-03-29)Background: The majority of patients with primary hyperparathyroidism (PHPT) in developed countries today present with no obvious symptoms, i.e. the mild form of the disease. As the only curative treatment is parathyroidectomy ... -
Modulation of Inflammatory Response in Surgical Trauma
(2012-09-12)Surgical trauma results in the activation of inflammatory cascade systems in the body. Excessive systemic inflammation can lead to organ dysfunction in one or several organs. The thesis aims to describe the body's inflammatory ... -
Molecular and cellular interactions on noble metal nanopatterned surfaces − applications towards bone, soft tissue and infection control
(2014-05-09)Biomaterial-associated infection is recognised as one of the main risks for failure of medical devices. The presence of a foreign material in tissues has been suggested to compromise the ability of host cells to eradicate ... -
Molecular and structural patterns of guided bone regeneration (GBR). Experimental studies on the role of GBR membrane and bone substitute materials
(2015-09-15)The mechanisms of guided bone regeneration (GBR) and bone healing with calcium phosphate (CaP) bone substitutes are not fully understood. The major aim of this thesis was to determine the relationship between the bone ... -
Molecular characterization of type I endometrial carcinomas
(2009-02-10)Endometrial carcinoma is the most common malignancy in the female reproductive tract. In Sweden over 1300 women are diagnosed every year, and although the prognosis is favourable in the majority of cases, about 160 ... -
Monitoring alveolar recruitment in the critically ill - Patient studies using electric impedance tomography and volume-dependent compliance
(2010-11-19)Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with a high mortality rate and poor long term outcome in terms of quality of life, for those who survive. Similarly, patients ... -
Monitoring cystic fibrosis lung disease in children - Clinical utility and associations between functional and structural methods
(2022-05-23)Background: Cystic Fibrosis (CF) is an inherited progressive disease that causes severe damage to the airways and other organs of the body. Many methods are available to track CF lung disease but longitudinal data are ... -
Morbidity and mortality following standardised perioperative management of patients operated with acute abdominal surgery in a high-risk emergency setting
(2023-11-06)Patients suffering from acute pathology in the abdomen is common throughout the world and surgical intervention can often be necessary. Those who are most seriously ill need an acute management with major abdominal surgery, ...