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Midkine in Advanced Prostate Cancer - Biological Impact and Biomarker Potential

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Title: Midkine in Advanced Prostate Cancer - Biological Impact and Biomarker Potential
Authors: Nordin, Anna
Issue Date: 15-Dec-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Urology
Parts of work: I. Nordin, A., Wang, W., Welén, K., Damber, JE. Midkine is associated with neuroendocrine differentiation in castration-resistant prostate cancer. Prostate. 2013; 73 (6): 657-67.

II. Nordin, A., Damber, JE., Welén, K. The role of Midkine in high-grade prostate cancer cells before and after steroid deprivation. Manuscript.

III. Nordin, A., Wang, W., Ahlgren, G., Josefssson, A., Welén, K., Damber, JE. Midkine as a progression biomarker in advanced prostate cancer. Manuscript

IV. Nordin, A., Welén, K., Damber, JE. Long-term steroid deprivation transforms prostate cancer cells to anaplastic castration resistant cells. Manuscript
Date of Defence: 2018-01-19
Disputation: Fredagen den 19 januari 2018, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Castration resistant prostate cancer
Neuroendocrine differentiation
Steroid deprivation
Abstract: Prostate cancer (PC) is generally an androgen-driven disease, why androgen deprivation therapy (ADT) is the cornerstone for treatment of advanced and metastatic hormone-naïve PC (HNPC). ADT generally offers a good initial response, but normally fails with time, and the disease relapses into lethal castration-resistant PC (CRPC). Neuroendocrine differentiation (NED) is a transdifferentiation process that results in the accumulation of neuroendocrine (NE)-like tumor cells. NED is increased in CRPC... more
ISBN: 978-91-629-0374-9 (PRINT)
978-91-629-0375-6 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper



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