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Molecular and cellular interactions on noble metal nanopatterned surfaces − applications towards bone, soft tissue and infection control


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/35771

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Title: Molecular and cellular interactions on noble metal nanopatterned surfaces − applications towards bone, soft tissue and infection control
Authors: Svensson, Sara
E-mail: sara.svensson@biomaterials.gu.se
Issue Date: 9-May-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Biomaterials
Parts of work: I. Suska F, Svensson S, Johansson A, Emanuelsson L, Karlholm H, Ohrlander M, Thomsen P. In vivo evaluation of noble metal coatings. Journal of Biomedical Materials Research. Part B, Applied Biomaterials 2010; 92(1): 86-94.
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II. Svensson S, Suska F, Emanuelsson L, Palmquist A, Norlindh B, Trobos M, Bäckros H, Persson L, Rydja G, Ohrlander M, Lyvén B, Lausmaa J, Thomsen P. Osseointegration of titanium with an antimicrobial nanostructured noble metal coating. Nanomedicine: Nanotechnology, Biology and Medicine 2013; 9(7): 1048-56.
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III. Svensson S, Forsberg M, Hulander M, Vazirisani F, Palmquist A, Lausmaa J, Thomsen P, Trobos M. Role of nanostructured gold surfaces on monocyte activation and Staphylococcus epidermidis biofilm formation. International Journal of Nanomedicine 2014; 9: 775-94.
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IV. Svensson S, Trobos M, Hoffman M, Norlindh B, Petronis S, Lausmaa J, Suska F, Thomsen P. A novel soft tissue model for biomaterial-associated infection and inflammation – bacteriological, morphological and molecular observations. In manuscript.
Date of Defence: 2014-05-28
Disputation: Onsdagen den 28 maj 2014, kl. 9.00, föreläsningssalen på våning 5, avdelningen för biomaterialvetenskap, Arvid Wallgrens backe 20
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: nanotopography
noble metals
titanium
biocompatibility
osseointegration
inflammation
host defence
monocytes
infection control
antimicrobial
staphylococci
Abstract: Biomaterial-associated infection is recognised as one of the main risks for failure of medical devices. The presence of a foreign material in tissues has been suggested to compromise the ability of host cells to eradicate infection. In addition, a protective biofilm formed by bacteria limits the effectiveness of administered antibiotics, which underscores the importance of preventive measures. The use of implant surface modifications that resist bacteria is a promising approach to reduce the inf... more
ISBN: 978-91-628-9005-6
URI: http://hdl.handle.net/2077/35771
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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