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Regulation of amyloid beta generation and its involvement in synaptic function: studies in human iPSC-derived cortical neurons
(2024-02-21)
Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and exerts a profound societal and economic impact. Clinically characterized by a gradual loss of memory, cognitive and ...
Dietary patterns among older adults - With focus on dementia and related biomarkers
(2022-10-18)
Background and aim: Diet is a lifestyle factor that can influence healthy ageing and the risk of developing dementia. Studies investigating dietary patterns among older adults in relation to dementia, and dementia-related ...
Novel cerebrospinal fluid and blood tau biomarkers in Alzheimer's disease and other neurodegenerative diseases
(2022-03-18)
Tau is a protein predominantly expressed in neurons in the central nervous system (CNS), where it binds microtubules (MT), playing a major role regulating their dynamics and architecture. Under pathological conditions, tau ...
Candidate biomarkers for synaptic pathology: neurogranin, neuroligins and neurexins in neurodegenerative disorders
(2021-05-14)
Synapses are small units through which neurons communicate in the brain. They represent the site of memory formation and cognitive abilities and are thus primarily affected by neurodegenerative diseases such as Alzheimer’s ...
Alzheimer's disease and vascular dementia in population-based studies
(2021-03-30)
Dementia, a clinical syndrome with several profiles and causes, is characterised by a decline in cognitive functions, including memory, learning, executive function, attention, language, and social ability. The most common ...
Fluid biomarkers of extracellular matrix remodelling across neurological diseases
(2021-02-12)
biomarkers to become beneficial, cost-effective, and easily accessible tools in neuroscience. The ambition of this thesis was to investigate if measurements of extracellular matrix proteins in human body fluids have a potential to characterise neurological...
The physiological processing of Alzheimer-associated amyloid beta precursor protein in human and animal-derived neuronal models
(2020-02-27)
Alzheimer’s disease (AD) is characterized by cognitive impairment due to the loss of structure and/or function of neurons, and amyloid plaques composed of aggregated-amyloid beta (Aβ) peptides, primarily species ending at ...
Multimodal Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
(2019-08-30)
Alzheimer’s disease (AD) is the most common form of dementia. AD has been linked to the aggregation of amyloid beta (Aβ) peptides into extracellular deposits, Aβ plaques. These are also found in cognitively unimpaired ...
Increasing the interpretability of Alzheimer-related biomarkers: cell- and cerebrospinal fluid-based studies with focus on neurogranin
(2019-05-07)
Biomarkers for Alzheimer’s disease (AD) is a growing field of research. A particularly vibrant field during recent years has been biomarkers for synaptic dysfunction. Sensitive assays for a synaptic protein called neurogranin ...
Biomarkers for Alzheimer's disease and the APOE polymorphism
(2019-04-18)
Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core pathology of AD are now widely used for diagnosis making, in particular β-amyloid[1-42] (Aβ42) ...