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Candidate biomarkers for synaptic pathology: neurogranin, neuroligins and neurexins in neurodegenerative disorders


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Title: Candidate biomarkers for synaptic pathology: neurogranin, neuroligins and neurexins in neurodegenerative disorders
Authors: Camporesi, Elena
E-mail: elena.camporesi@gu.se
Issue Date: 14-May-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: Becker, B., Nazir, F. H., Brinkmalm, G., Camporesi, E., Kvartsberg, H., Portelius, E., Bostrom, M., Kalm, M., Hoglund, K., Olsson, M., Zetterberg, H., and Blennow, K. (2018) Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase. Mol Neurodegener 13: 47.
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Nazir, F. H., Camporesi, E., Brinkmalm, G., Lashley, T., Toomey, C. E., Kvartsberg, H., Zetterberg, H., Blennow, K., and Becker, B. (2020) Molecular forms of neurogranin in cerebrospinal fluid. J Neurochem
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Elena Camporesi, Tammaryn Lashley, Johan Gobom, Juan Lantero Rodriguez, Oskar Hansson, Henrik Zetterberg, Kaj Blennow, Bruno Becker. Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers. Acta Neuropathol Communications 2021.
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Elena Camporesi, Johanna Nilsson, Agathe Vrillon, Emmanuel Cognat, Claire Hourregue, Henrik Zetterberg, Kaj Blennow, Bruno Becker, Ann Brinkmalm, Claire Paquet and Gunnar Brinkmalm. Quantification of the trans-synaptic partners neuroligin-neurexin in CSF of neurodegenerative diseases by parallel reaction monitoring mass spectrometry. Manuscript
Date of Defence: 2021-06-04
Disputation: Fredagen den 4 Juni 2021, kl. 9.00, i R-aulan, Hus R, SU/Mölndals sjukhus, Mölndal. https://videoapi.vgregion.se/meet/4/boWBRk6xRA/1904f5daDD
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Synaptic dysfunction
Alzheimer’s disease
Biomarkers
Neurogranin
Neurexins
Neuroligins
Cerebrospinal fluid
Brain tissue
Abstract: Synapses are small units through which neurons communicate in the brain. They represent the site of memory formation and cognitive abilities and are thus primarily affected by neurodegenerative diseases such as Alzheimer’s disease (AD), the leading cause of dementia in the elderly population. Despite great research efforts, there is no definitive cure to date. Moreover, AD diagnosis is challenged by comorbidities and the long prodromal asymptomatic disease stage that conceal early pathological c... more
ISBN: 978-91-8009-303-3 (PDF)
978-91-8009-302-6 (Print)
URI: http://hdl.handle.net/2077/68063
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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