Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 304-323 of 480
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On the importance of inflammation for personality traits and psychiatric morbidity
(2010-12-10)Background: Pro-inflammatory mediators have been implicated in processes that could be both beneficial and toxic to cells in the brain. On the one hand balanced levels of these mediators favour e.g. neurodevelopmental ... -
On the influence of dopamine-related genetic variation on dopamine-related disorders
(2009-11-13)Rationale: Dopamine synthesizing neurons are involved in a wide variety of functions. The most prominent dopamine pathways originate in the midbrain. The development, function and survival of these dopaminergic neurons are ... -
On the influence of serotonin- and sex steroid-related genetic variation on mood, anxiety, personality, autism and transsexualism
(2008-10-17)Background: The neurotransmitter serotonin has been related to mood and anxiety, and variation in genes that encode important members of the serotonergic system may hence affect mood- and anxiety-related traits. Sex steroids ... -
On The Innervation of Salivary Glands and Treatment of Dry Mouth - An Experimental and Clinical Study
(2009-11-19)Detailed knowledge of the innervation of the parotid gland is essential in basic studies on various neuroglandular phenomena as well as in various types of orofacial surgery. The innervation is more complex than usually ... -
On the prevention of migraine -focus on exercise and the patient's perspective
(2012-02-03)ABSTRACT Migraine is a common neurological disorder causing huge suffering both for the individuals affected and for society. As migraine is a chronic disorder that cannot be cured, but merely relieved, prevention is of ... -
On the Regulation of the Serine Protease t-PA and its Inhibitor PAI-1 in the Brain
(2010-09-28)The serine protease tissue-type plasminogen activator (t-PA) is the main fibrinolytic enzyme in the vascular system, and thus plays a critical role in the dissolution of thrombi. In recent years, researchers have focused ... -
On the Stereoselective Pharmacokinetics of Eflornithine and Prediction of Drug Tissue to Plasma Concentration Ratios
(2009-09-18)Eflornithine is one of two registered drugs for the treatment of late-stage human African trypanosomiasis, a uniformly fatal neglected disease with sixty million people are at risk of being infected. Eflornithine is ... -
On the Surgical Management of Diffuse Low-Grade Gliomas in Adults
(2023-11-10)Diffuse low-grade gliomas (dLGG) are rare, slow-growing, yet difficult-to-treat brain tumors that typically affect young to middle-aged adults. The aim of the thesis has been to identify factors affecting management and ... -
On the use of genomics to assess environmental risks of pharmaceuticals
(2009-12-17)Many drugs are found in the aquatic environment and are therefore a cause for concern. Low concentrations of active ingredients from human pharmaceuticals reach the environment via sewage treatment plants, mainly as a ... -
Optimization of first-line anti-tuberculosis therapy in patients co-infected with HIV
(2021-09-24)Every year over one million people die from tuberculosis. People infected with HIV are significantly more vulnerable to tuberculosis, which is the leading cause of HIV-associated death. The first-line treatment for ... -
Optimization of HIV therapy in patients co-infected with tuberculosis: a pharmacogenetic and pharmacokinetic study of efavirenz in Rwandan adult patients undergoing HIV and tuberculosis co-treatment
(2013-11-27)Tuberculosis (TB) is the most common opportunistic infection among people infected with human immunodeficiency virus (HIV). The co-management of HIV/TB co-infection is prone to multiple drug-drug interactions. In addition, ... -
Oral eflornithine treatment of late-stage human African trypanosomiasis
(2022-11-21)Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African ... -
Orofacial dysfunctions in children and adolescents with myotonic dystrophy type 1 - evaluation and intervention
(2010-05-12)Myotonic dystrophy type 1 (DM1) is a slowly progressive neuromuscular disease. The overall aim of this thesis was primarily to describe the characteristics, prevalence, and development of orofacial functions in a group of ... -
Oropharyngeal dysphagia in adults: Prevalence, professional practices, patient perspectives and treatment outcomes
(2023-05-25)Background: Oropharyngeal dysphagia (OD) is defined as any disruption in the transportation of food/liquids safely and efficiently from the mouth, through the pharynx and into the esophagus. The underlying causes of OD ... -
Orthoptic Findings and Visual Fixation in children in general and in children with surgically treated hydrocephalus
(2007-04-11)Background: The ocular motor system is complex and dependent on the cooperation of many different areas of the brain. Ocular motor functions may be disturbed by various factors resulting in strabismus, and abnormal fixational ... -
Outcome after modern neurosurgical care and formalised rehabilitation following severe brain injury
(2010-05-28)Aims: The overall aims were to evaluate the results of the treatment concepts for severe brain injury including decompressive craniectomy (DC), early rehabilitation and long-term follow-up, primarily according to the ... -
Outcome after treatment of cerebral aneurysms
(2024-02-08)A cerebral aneurysm is a saccular or tubular-like deformity of the arterial vessel wall which is usually thinner. The rupture of a cerebral aneurysm is associated with a high morbidity and mortality by causing an aneurysmal ... -
Paracrine control of glucagon secretion in the pancreatic α-cell: Studies involving optogenetic cell activation
(2020-06-12)ABSTRACT The mechanisms controlling glucagon secretion by α-cells in islets of Langerhans were studied. We generated mice with the light-activated ion channel ChR2 specifically expressed in β-, α-, and δ-cells, and ... -
Parkinson's disease and motor function - a validation of the PLM method
(2013-09-27)Aim: To validate the Posturo-Locomotor-Manual (PLM) test, an objective movement measurement system designed to measure movement disability in patients with Parkinsonism. Method: The reliability of the PLM test was determined ... -
Participation after stroke in a short- and long-term perspective
(2019-10-15)The main scope of this thesis was to study and describe perceived participation among persons with stroke. In doing so, different timepoints were chosen to make a more complete picture of participation after stroke. The ...