Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 253-272 of 480
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Mentally disordered offenders: a longitudinal study of forensic psychiatric assessments and criminal recidivism
(2013-08-27)Background: During history, mentally disordered offenders have been in focus regarding responsibility for their crimes and imposition of punishment. The boundary stone of legal consequences for mentally ill offenders has ... -
Metabolic and immunological interactions between adipose tissue and breast cancer - implications of obesity in tumor progression
(2019-10-16)Triple-negative breast cancers have fewer treatment options than other breast cancers. The overall goal of this research is to identify new pharmaceutical targets for triple-negative breast cancer through studies of the ... -
Metabolic and ovarian consequences of perinatal sex steroid programming
(2008-11-24)Endocrine and metabolic disturbances in adulthood may stem from insults such as nutritional and hormonal alterations that occur at critical periods in pre- or postnatal life – a process known as programming. This means ... -
Microglial Glutamate Transporters - Regulation of Expression and Possible Physiological Functions
(2007-05-15)Microglia are considered as the immunocompetent cells of the central nervous system (CNS). Being the first line of defence, they have prominent roles in monitoring the homeostasis and the extracellular milieu and can rapidly ... -
Mild Cognitive Impairment - concepts, cut-offs, and clinical relevance
(2019-04-25)Mild cognitive impairment (MCI) is a diagnosis frequently used in dementia research and in memory clinics. MCI is meant to identify patients without dementia, but with cognitive decline beyond what is considered normal, ... -
Mild intellectual disability: Diagnostic and outcome aspects
(2013-11-29)The aim of the thesis was to describe mild intellectual disability (ID) from various neurodevelopmental and neuropsychiatric perspectives in children and young adults. Paper I The objective of the first paper was to ... -
Mild stroke - consequences in everyday life, coping and life satisfaction.
(2007-04-25)Abstract Aim: The aim of this thesis was to explore the life situation one year after an apparently mild stroke, and to compare life satisfaction between patients and their spouses. Method: Seventy-five patients with ... -
Modelling of tolerance and rebound in normal and diseased rats
(2011-05-27)The development of rebound and tolerance is an important consideration when optimizing medical therapy, both with respect to drug dosing and adverse effects. By using quantitative approaches to study these processes, ... -
Molecular and physiological regulation of adiponectin exocytosis in white adipocytes
(2015-11-23)In this thesis we have investigated the mechanisms of white adipocyte regulated exocytosis in health and disease, with a special focus on adiponectin. We have applied a combination of electrophysiological membrane capacitance ... -
Molecular perspectives on glomerular cell physiology in chronic kidney disease
(2019-05-24)Glomerulonephritis is one of the most common causes of chronic kidney disease (CKD) in the world. Recent establishment of guidelines for classification of CKD in five stages has led to increased awareness of the risks of ... -
Moved by movement: A person-centered approach to physical therapy in the treatment of major depression
(2015-05-12)Major depression (MD) is a common and debilitating condition. To expand knowledge on adjunctive treatment perspectives, this thesis explores a physical therapy approach in the treatment of MD. Specifically, in five studies, ... -
A Multimodal Approach toward the Biological Categorization of Autism - Development of Theoretical Models, Classification Methods, and Biomarkers
(2022-11-18)Autism Spectrum Disorder (ASD) is an umbrella term for a group of neurodevelopmental disorders (NDD) which are behaviorally defined by the presence of difficulties with social communication, and behavioral rigidity and ... -
Multimodal Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
(2019-08-30)Alzheimer’s disease (AD) is the most common form of dementia. AD has been linked to the aggregation of amyloid beta (Aβ) peptides into extracellular deposits, Aβ plaques. These are also found in cognitively unimpaired ... -
Muscarinic receptors in the urinary bladder - The role of the urothelium regarding cholinergic and nitrergic effects in inflammation
(2010-11-19)Inflammation alters the functional properties of the urinary bladder. Interstitial cystitis (IC) is a chronic inflammatory syndrome in man that is characterized by urgency, frequency and visceral pain. The overall aim of ... -
Muscle diseases with damaged sarcomeres - causes and consequences
(2011-01-19)Muscle diseases, also called myopathies, are usually defined as diseases where the pathology is confined to the muscle itself. This excludes diseases caused by structural abnormalities in the peripheral nerve, from the ... -
Muscle strength and resistance exercise in women with fibromyalgia - a person-centered approach
(2018-05-15)Fibromyalgia (FM) is characterized by generalized pain and associated with impaired physical capacity and activity limitations. Low-intensity exercise has been shown to be a safe way to exercise without risking an increase ... -
N-acetylaspartate in brain - studies on efflux and function
(2006-10-16)N-acetylaspartate (NAA) is an amino acid derivative present in high concentration in the brain. The function of NAA is still unsettled in spite of 50 years of research. The mainly neuronal synthesis and glial breakdown of ... -
Natural course and long-term prognosis in idiopathic Normal Pressure Hydrocephalus - the effect of delayed surgery and clinical factors on outcome and survival
(2020-05-07)Idiopathic Normal Pressure Hydrocephalus, iNPH, causes gait and balance difficulties, urinary incontinence and cognitive decline in mainly older persons and is treatable by insertion of a cerebrospinal fluid diverting ... -
Natural History of Human Papillomavirus Infections and Other Sexually Transmitted Infections in Rwanda-Immunological Aspects of the Uterine Cervix
(2018-11-23)Objective: Cervical cancer stands for the predominant cause of cancer death among Rwandan women. Chronic Human Papillomavirus (HPV) infection constitutes the main risk factor. We here assessed the prevalence and incidence ... -
Navigating towards a self-determined daily life in old age. Experiences, instrument evaluation and explanatory factors.
(2015-05-18)Aim: The overall aim of this thesis was to explore self-determination in the context of community-dwelling older persons with different degrees of dependence in daily activities. Methods: Using a qualitative, grounded ...