Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
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Intracranial volume in neuroimaging: estimation and use in regional brain volume normalization
(2019-02-15)The aim of this thesis is to validate methods for estimation of intracranial volume in magnetic resonance images and to improve our understanding of the effect of intracranial volume normalization. To achieve the first ... -
Investigation of the pathophysiology of progression in multiple sclerosis: studies on cerebrospinal fluid biomarkers
(2013-04-23)Multiple Sclerosis (MS) is considered an autoimmune disease of the central nervous system (CNS). It usually starts with a relapsing remitting (RR) course that eventually transforms into progressive (P)MS, showing ... -
Investigations into the role of Epstein-Barr virus in the pathogenesis of multiple sclerosis
(2022-09-08)Epstein-Barr virus (EBV) infection may be a prerequisite for the development of MS. Virtually all MS patients have antibodies to Epstein Barr virus nuclear antigen 1 (EBNA1), compared to 90-95% of healthy individuals. ... -
Investigations of human cortical processing of gentle touch. A study with time-resolved electro-magnetic signal analysis
(2019-04-12)The present work summarizes investigations of the temporal correlates of brain activity elicited by gentle, moving touch on the hairy skin in healthy participants and in epilepsy patients. Light touch to the hairy skin ... -
Irradiation-induced injury to the juvenile brain -Roles of sex and inflammation
(2013-11-14)Radiotherapy is commonly used in the treatment of pediatric malignancies, but unfortunately it is associated with negative side effects, both long-term and short-term. Negative side effects following cranial irradiation ... -
It´s never too late
(2014-04-15)The overall aim of this thesis was to evaluate the effects of health-promoting and disease-preventive interventions on health and frailty in very old community-dwelling persons, and to explore the participants’ experiences ... -
Labile glutamate synaptic transmission onto CA1 hippocampal pyramidal neurons: regional, functional and developmental diversity
(2024-02-14)A single neuron in the brain receives tens of thousands of glutamate synapses from other neurons, and these synapses can differ in their properties depending on their role in the neural circuit, during brain development ... -
Language ability in patients with low-grade glioma - detecting signs of subtle dysfunction
(2017-11-17)Background: Low-grade glioma (LGG) is a slow-growing brain tumour often situated in or near areas involved in language and/or cognitive functions. Consequently, there is a risk that patients develop language impairments ... -
Language problems at 2½ years of age and their relationship with school-age language impairment and neuropsychiatric disorders
(2007-01-03)Background: International research has shown that language delay (LD) is associated with social, cognitive, emotional and/or behavioural deficiencies, but there is still a need for extended knowledge about LD at early age ... -
Late Neuropsychiatric Consequences of Stroke in the Elderly
(2006-11-07)Cognitive impairments and depression have considerable impacts on rehabilitation, quality of life and mortality after stroke. The understanding of cognitive and mood impairments in old and, in particular, very old stroke ... -
Learning for life - How children with unilateral spastic cerebral palsy learn to master bimanual activities
(2018-09-03)Background: For children with unilateral spastic cerebral palsy (USCP), activities in daily life pose a challenge due to reduced function in one hand. Aim: To study the development of hand function and occupational ... -
Let’s stay in touch! Remote communication for people with communicative and cognitive disabilities
(2018-12-13)Introduction: Being able to use remote communication through digital channels is a prerequisite for participation in contemporary society, but some people have difficulties in accessing it. Aim: The overall aim was to ... -
Life after hip fracture - Impact of home rehabilitation versus conventional care and patients' experiences of the recovery process in a short- and long-term perspective
(2008-10-14)Aim In a short- and long-term perspective compare a geriatric home rehabilitation programme (HR) for patients with hip fracture with conventional care (CC), and to capture the patients experience of the consequences of ... -
Life is doing. Facilitators and hindrances for occupational performance in adults with cerebral palsy - including methods of intervention
(2019-12-12)Introduction: Occupational performance is a complex process which poses difficulties to persons with CP even where they have relatively good motor function. Aim: To explore and describe the perception of occupational ... -
Lithium protects the juvenile brain from ionizing radiation
(2015-10-14)Radiotherapy used in the treatment of brain tumours in children results in a range of cognitive dysfunctions that impact the quality of life in the surviving population. In past decades, great strides were made in understanding ... -
Living with ALS – Perspectives of Patients and Next of kin
(2010-05-28)ALS is a neurodegenerative disease without curative treatment. The knowledge of the relationship between patients and their next of kin with respect to quality of life (QoL) is deficient. The overall aim of this thesis is ... -
lmproving diagnosis of central nervous system tumours using genetic and epigenetic tools
(2023-05-09)Brain tumor diagnostics has traditionally been based on histopathology stains. The introduction of immunohistochemistry stains resulted in improved ability to classify these often devastating tumors. The understanding of ... -
lnduction Therapies in Multiple Sclerosis - Clinical and immunological follow-up
(2024-03-21)Multiple sclerosis (MS) is a chronic disease that damages the central nervous system. Its pathophysiology is complex, and consists of inflammation and degeneration from the disease onset. The treatment of MS has continuously ... -
lnternalizing problems in childhood and adolescence: predictive, etiological, and neurodevelopmental aspects
(2021-11-25)Internalizing disorders such as anxiety and depressive disorders are common mental disorders in childhood and adolescence. They are characterized by disordered emotions and moods, causing emotional distress and impairment. ... -
lnvestigating intestinal smooth muscle dysfunction in the 6-OHDA rat model of Parkinson's disease
(2022-05-27)The neurodegenerative progression of the nigrostriatal pathway in Parkinson’s disease (PD) entails the appearance of motor and nonmotor symptoms. Nonmotor symptoms are common, having a negative impact on the quality of ...