Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 55-74 of 347
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Commensal microbes, immune reactivity and childhood inflammatory bowel disease
(2009-06-29)Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal inflammation of unknown etiology, but immune activation by the commensal microbiota probably plays a major role. The two major categories ... -
Community onset sepsis in Sweden - a population based study
(2017-11-17)Sepsis and previously “severe sepsis” are concepts used for denoting organ dysfunction caused by acute infection. Organ dysfunction correlates to increased case fatality rates. Sepsis is a common cause of hospitalization. ... -
Comprehensive analysis of structural genomic alterations in cancer
(2018-02-13)The transformation of a normal cell into a cancer cell involves the accumulation of somatic DNA alterations that confer growth and survival advantages. These genomic alterations can be different in terms of pattern and ... -
Computational analysis of oligosaccharide conformations – methodological development, applied studies, and design of glycomimetics
(2010-05-28)Carbohydrates are the most abundant class of biomolecules. Besides their roles as structural elements and energy storage, they are involved in signaling and recognition processes. Their functions and activities depend on ... -
Computational exploration of cancer genomes
(2019-01-09)Cancer evolves due to changes in DNA that give a cell an advantage at the expense of the remaining organism. These alterations range from individual base substitutions to broad losses or duplications of chromosomal material. ... -
Computational identification of non-coding RNAs
(2007-01-12)A large amount of genomic information is now becoming available. Suitable bioinformatic tools to organize and analyze this vast amount of information are therefore important. In the case of protein genes, the majority of ... -
Computational studies of mutational sequence signatures in cancer genomes
(2021-10-08)Cancer typically forms when mutational processes modify key cancer driver genes, resulting in positive selection and tumor growth. As such, mutational processes are at the core of the disease. Trinucleotide mutational ... -
Consequences of meticillin-resistant Staphylococcus aureus (MRSA) acquisition. Patient experiences and interactions in health care and daily life.
(2014-11-04)Aims. The overall purpose of this thesis was to follow up the consequences of guidelines installed to prevent transmission of MRSA in healthcare from the patients’ point of view and subsequent consequences for everyday ... -
The contribution of proteins and lipids to COPI vesicle formation and consumption
(2008-11-18)In the secretory pathway, movement of proteins between compartments occurs through small (50-100 nm) vesicles. The coat of COPI vesicles is composed the small GTPase ARF1 and the large coatomer complex. In the secretory ... -
Crisis in Energy Metabolism - Mitochondrial Defects and a New Disease Entity
(2006-12-08)Impairment of energy metabolism may be associated with severe implications for affected individuals since all fundamental cell functions are energy-dependent. Disorders of energy metabolism are often genetic and associated ... -
Cytomegalovirus Infection in Heart and Lung Transplant Patients with focus on long-term outcome
(2014-11-06)Cytomegalovirus (CMV) infection is a common opportunistic infection after heart and lung transplantation. The aims of this thesis were to relate the incidence and severity of CMV infection and disease to different forms ... -
Defining the pathways involved in spatial protein quality control in Saccharomyces cerevisiae
(2022-11-21)Proteins need to be folded into specific three-dimensional conformations to be functional. An extensive network of factors, the protein quality control (PQC) machinery, ensures that the cell maintains a healthy proteome ... -
Delineating cellular heterogeneity and organization of breast cancer stem cells
(2015-12-02)Breast cancer is characterized by a high degree of heterogeneity in terms of histological, molecular and clinical features, affecting disease progression and treatment response. The cancer stem cell (CSC) model suggests, ... -
Dendritic cell maturation and death during Salmonella infection. Role of pro-inflammatory cytokines and MyD88
(2007-12-21)The costimulatory molecules CD80 and CD86 are required for the ability of dendritic cells (DC) to induce both tolerance and immunity. This thesis investigates the control of CD80/CD86 upregulation in vivo on DC during ... -
Dendritic cells and B cells in effector T cells decisions - promotion of antibody induction in lymphoid tissues or gut homing
(2018-05-14)Abstract CD4+ T cells are principal cells of the adaptive immune system, equipped with the ability to boost innate immune cells and aid B cells in the germinal centers. Every T cell clone carries a variable and unique T ... -
Deregulated epigenetics and cancer stem cells in brain tumours
(2022-05-11)Glioblastoma (GBM) is an incurable brain tumour with dismal prognosis as the median survival for afflicted patients is only 8 months. Aberrations of epigenetic processes, which govern gene expression, are involved in cancer, ... -
Derivation, Characterization and Differentiation of Feeder-Free Human Embryonic Stem Cells
(2010-05-17)Human embryonic stem cells (hESCs) are pluripotent cells with self-renewal ability, derived from the inner cell mass of a human blastocyst. They have the remarkable potential to develop into different cell types and can ... -
Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals
(2013-11-11)The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of ... -
Development of novel immunization approaches to generate immunity in the female genital tract with special reference to genital herpes
(2007-08-22)Development of mucosal vaccines for inducing immunity in the female reproductive tract would have profound implications for the prevention of sexually transmitted diseases. Despite numerous efforts, no such vaccines are ... -
Development of novel vaccine strains of Vibrio cholerae and studies on the role of serotype in epidemic spread of cholera
(2014-09-26)Cholera, caused by bacterium Vibrio cholerae O1, is a severe diarrheal disease with an estimated 3-5 million cases and more than 140 000 deaths every year particularly affecting children under 5 years of age. It can be ...