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Computational exploration of cancer genomes

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Title: Computational exploration of cancer genomes
Authors: Karlsson, Joakim
Issue Date: 9-Jan-2019
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Biochemistry and Cell Biology
Parts of work: I. Mutational signature and transcriptomic classification analyses as the decisive diagnostic tools for a cancer of unknown primary. *Olofsson Bagge R, *Demir A, *Karlsson J, Alaei-Mahabadi B, Einarsdottir BO, Jespersen H, Lindberg MF, Muth A, Nilsson LM, Persson M, Svensson JB, Söderberg EMV, de Krijger RR. Nilsson O, Larsson E, Stenman B and Nilsson JA. JCO Precision Oncology. 2018.

II. FocalScan: Scanning for altered genes in cancer based on coordinated DNA and RNA change. Karlsson J and Larsson E. Nucleic Acids Research. 2016; 44 (19): e150.

III. Molecular profiling of driver events and infiltrating T-cells in metastatic uveal melanoma. Karlsson J, Nilsson LM, Forsberg EMV, Mitra S, Alsén S, Stierner U, All-Eriksson C, Green L, Einarsdottir B.O, Jespersen H, Belgrano V, Nilsson Wassen O, Ny L, Lindnér P, Larsson E, Olofsson Bagge R and Nilsson J.A. Manuscript
Date of Defence: 2019-01-30
Disputation: Onsdagen den 30 januari 2019, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Cancer genomics
Driver genes
Copy number changes
Cancer of unknown primary
Uveal melanoma
Abstract: Cancer evolves due to changes in DNA that give a cell an advantage at the expense of the remaining organism. These alterations range from individual base substitutions to broad losses or duplications of chromosomal material. This thesis explores how DNA and RNA sequencing can guide discovery of altered genes responsible for cancer development, profile the immune landscapes of tumors and support the diagnosis of difficult cases. In the first of three studies, we examined DNA and RNA from the tum... more
ISBN: 978-91-7833-291-5 (PDF)
978-91-7833-290-8 (PRINT)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin



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