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Commensal microbes, immune reactivity and childhood inflammatory bowel disease


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/20528

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Title: Commensal microbes, immune reactivity and childhood inflammatory bowel disease
Authors: Barkman, Cecilia
E-mail: cecilia.barkman@microbio.gu.se
Issue Date: 29-Jun-2009
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Infectious Medicine
Parts of work: I. Barkman C., Saalman, R., Lindberg E., Wolving M., Ahrné S., Molin G., Adlerberth I., Wold A.E. Intestinal microbiota at début of childhood inflammatory bowel disease. In manuscript

II. Barkman C., Saalman, R., Rudin A., Wold A.E. Activation, homing and memory markers on blood circulating B and T lymphocytes at début of childhood inflammatory bowel disease. In manuscript.

III. Barkman C., Martner A., Hessle C., Wold A.E. Soluble bacterial constituents down-regulate secretion of IL-12 in response to intact Gram-positive bacteria. Microbes and Infection 10 (2008) 1484-93.
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Date of Defence: 2009-05-28
Disputation: Torsdagen den 28 maj 2009, kl. 13.00, Hörsalen på Bakteriologiska laboratoriet, SU/Sahlgrenska, Guldhedsgatan 10A, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Inflammatory bowel disease
IBD
Pediatric
Childhood
Microbiota
T cells
B cells
cytokine
IL-12
monocytes
phagocytosis
intracellular signaling pathway
Crohn's disease
ulcerative colitis
children
flora
Abstract: Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal inflammation of unknown etiology, but immune activation by the commensal microbiota probably plays a major role. The two major categories of IBD are ulcerative colitis and Crohn’s disease. One fifth of the cases present in childhood and Sweden has a high and rising incidence of pediatric IBD. The aim of this thesis was to study the composition of the small and large intestinal microbiota and signs of activation... more
ISBN: 978-91-628-7811-5
URI: http://hdl.handle.net/2077/20528
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

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