Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 165-184 of 347
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Immunotherapy and immunosuppression in myeloid leukemia
(2018-11-12)Acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) are potentially life-threatening blood cancers characterized by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis ... -
Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection
(2020-04-23)Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on ... -
Impact of Host Genetic Variants on Natural History and Treatment of Hepatitis C Virus Infection
(2015-01-30)Chronic hepatitis C Virus (HCV) infection causes liver disease and may progress to severe fibrosis, cirrhosis, and hepatocellular carcinoma. This thesis aimed to evaluate the impact of host genetics, i.e. genetic variants ... -
Impact of NK cell repertoires on immunotherapy in acute myelod leukemia
(2017-11-08)Natural killer (NK) cells are lymphocytes endowed with cytotoxicity against aberrant cells, including transformed and virus-infected cells. NK cell function is dictated by a fine-tuned interplay between activating and ... -
In vitro toxicity testing using human pluripotent stem cell derivatives
(2016-11-23)Toxicity testing of chemicals, drug candidates, and food additives is in need of a change. The present methods, mainly consisting of animal models with their associated ethical concerns, are expensive, time-consuming, and ... -
Infant microbiota and short chain fatty acids - relation to lifestyle and effect on health
(2023-09-21)The commensal microbiota has both beneficial and negative effects on the host. It is a source of infectious and inflammatory microorganisms, but may also provide immune stimulation during a critical period during early ... -
Infections associated with percutaneous osseointegrated titanium implants for limb prostheses
(2017-10-26)Femoral amputation is a devastating event. Percutaneous, bone anchored prosthetic systems reduce problems associated with socket suspended prostheses, but the design is inherently vulnerable to infection. The aims of this ... -
Inflammatory mediator response to Gram-positive and Gram-negative bacteria in vitro and in middle ear infections
(2010-02-12)Based on the structure of the cell wall, bacteria are divided into Gram-positive and Gram-negative. While the cell wall of Gram-positive bacteria is thick, the cell wall of Gram-negatives is very thin and surrounded by an ... -
Inhibition of HIV-1 and HSV-2 infection by glycosaminoglycan mimetics
(2013-10-08)HIV-1 is a sexually transmitted pandemic pathogen that causes progressive defects in cell-mediated immunity for which curative treatment and prophylaxis are lacking. In addition to CD4 and chemokine receptors of protein ... -
Initiation of Mammalian Mitochondrial DNA Replication
(2014-04-04)Mitochondria produce most of the adenosine triphosphate required in a eukaryotic cell and they contain their own genome. The mitochondrial DNA (mtDNA) is a double stranded circular molecule that codes for proteins required ... -
The interactome of the Epstein-Barr virus nuclear antigen 5 suggests novel roles in RNA and protein metabolism
(2010-01-19)Epstein-Barr virus (EBV) is a human herpes virus that infects B and epithelial cells of the oropharynx. EBV is transmitted by saliva and establishes a lifelong latency in over 90% of the world's population. During latency, ... -
Interplay between Pathogenic and Immune Regulatory Mechanisms in G-alpha-i2 deficient colitis
(2011-12-20)The two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC) are gastrointestinal disorders characterized by chronic and relapsing inflammation. Mice deficient in the inhibitory ... -
Interpretation of diagnostic information given patient characteristics
(2006-10-20)The aim with this thesis was to describe, exemplify and develop theory for reference values and diagnostic tests, especially focusing on the variability between individuals. To facilitate interpretation of medical information ... -
Intestinal IgA synthesis: Localization and requirements for IgA class switch recombination
(2009-09-03)Production of IgA at mucosal surfaces is one of the most striking features of the mucosal immune system. Despite that IgA was first discovered in the 1950’s and secretory IgA described in gut secretions and breast milk ... -
Intracellular regulation of TLR signaling Basic mechanisms and importance in intestinal inflammation
(2011-04-21)Toll-like receptors (TLRs) recognize conserved structures on/in microorganisms. The intracellular signalling pathways of TLRs are shared with IL-1R and IL-18R and their activation leads to transcription of proinflammato ... -
Invasive fungal disease in immunocompromised hosts with focus on diagnostics
(2019-04-12)Invasive fungal diseases (IFDs) are severe conditions affecting immunocompromised patients. The primary aim of this thesis was to explore different methods for diagnosis of IFD in different groups of immunocompromised ... -
Invasive Pneumococcal Infections
(2011-12-21)Streptococcus pneumoniae is a major cause of disease, ranging from uncomplicated respiratory infections to severe invasive pneumococcal disease (IPD), including bacteraemic pneumonia, septicaemia with unknown focus and ... -
Invasive Staphylococcus aureus infections
(2009-11-27)Staphylococcus aureus is a leading cause of septicaemia-related death. The aims of this thesis were to describe the epidemiology of invasive Staphylococcus aureus infections (ISA), the clinical course, and serological ... -
Investigating ALK inhibitors alone or in combination as therapeutic options for ALK-positive neuroblastoma
(2021-11-16)Neuroblastoma (NBL) is the third most common pediatric cancer after leukemia and cranial tumours and accounts for around 15% of death in pediatric malignancy. NBL develops due to the poorly differentiated progenitor cells ... -
Ischemic Stroke Outcomes - Analyses of Protein and Genetic Biomarkers
(2019-04-18)The overall aim of this thesis was to identify novel biomarkers for ischemic stroke outcomes. The specific aims were to test the hypotheses that circulating concentrations of hemostatic biomarkers predict the long-term ...