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Immunotherapy and immunosuppression in myeloid leukemia


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Title: Immunotherapy and immunosuppression in myeloid leukemia
Authors: Hallner, Alexander
E-mail: alexander.hallner@gu.se
Issue Date: 12-Nov-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Infectious Diseases
Parts of work: 1. Aurelius J*, Hallner A*, Werlenius O, Riise R, Möllgård L, Brune M, Hansson M, Martner A, Thorén FB, Hellstrand K. NOX2‐dependent immunosuppression in chronic myelomonocytic leukemia.
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2. Rydström A*, Hallner A*, Aurelius J, Sander FE, Bernson E, Kiffin R, Thoren FB, Hellstrand K, Martner A. Dynamics of myeloid cell populations during relapse‐preventive immunotherapy in acute myeloid leukemia.
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3. Bernson E, Hallner A, Sander FE, Wilsson O, Werlenius O, Rydström A, Kiffin R, Brune M, Foà R, Aurelius J, Martner A, Hellstrand K, Thorén FB. Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia.
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4. Bernson E, Hallner A, Sander FE, Nicklasson M, Nilsson MS, Christenson K, Aydin E, Liljeqvist JÅ, Brune M, Foà R, Aurelius J, Martner A, Hellstrand K, Thorén FB. Cytomegalovirus serostatus affects autoreactive NK cells and outcomes of IL2-based immunotherapy in acute myeloid leukemia.
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5. Hallner A, Bernson E, Hussein BA, Sander FE, Brune M, Aurelius J, Martner A, Hellstrand K, Thorén FB The HLA-B -21 dimorphism impacts on NK cell education and clinical outcome of immunotherapy in acute myeloid leukemia
Date of Defence: 2018-11-29
Disputation: Torsdagen den 29 november 2018, kl. 9:00, Hörsal Björn Folkow, Medicinaregatan 11, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Natural killer cells
acute myeloid leukemia
histamine dihydrochloride
immunotherapy
reactive oxygen species
chronic myelomonocytic leukemia
NK cell education
NKG2A
HLA
KIR
Abstract: Acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) are potentially life-threatening blood cancers characterized by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis aimed at contributing to the understanding of the role of natural killer (NK) cells in AML and CMML with focus on the potential impact of the immunosuppression exerted by reactive oxygen species (ROS) formed by the myeloid cell NOX2 enzyme. The thesis work has comprised in vitr... more
ISBN: 978-91-7833-201-4
978-91-7833-202-1
URI: http://hdl.handle.net/2077/56919
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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