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Impact of NK cell repertoires on immunotherapy in acute myelod leukemia


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/52867

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Title: Impact of NK cell repertoires on immunotherapy in acute myelod leukemia
Authors: Bernson, Elin
E-mail: elin.bernson@gu.se
Issue Date: 8-Nov-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Infectious Diseases
Parts of work: I. Bernson E, Hallner A, Sander F E, Wilsson O, Werlenius O, Rydström A, Kiffin R, Brune M, Foà R, Aurelius J, Martner A, Hellstrand K, Thorén F B. Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia. Leukemia, 2017; Epub ahead of print
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II. Bernson E, Hallner A, Sander F E, Nicklasson M, Nilsson M, Christenson K, Aydin E, Liljeqvist J-Å, Brune M, Foà R, Aurelius J, Martner A, Hellstrand K, Thorén F B. Cytomegalovirus regulates autoreactive NK cells and prognosticates the outcome of IL-2-based immunotherapy in acute myeloid leukemia. Submitted

III. Hallner A, Bernson E, Hussein B A, Sander F E, Brune M, Foà R, Aurelius J, Martner A, Hellstrand K, Thorén F B. Impact of HLA-B -21 dimorphism on clinical outcome of IL-2-based immunotherapy in acute myeloid leukemia. In manuscript

IV. Bernson E*, Christenson K*, Pasanen M, Hellstrand K, Bylund J, Thorén F T. Dynamic modulation of NK cell receptor ligands in inflammatory neutrophils. In manuscript. *Authors contributed equally
Date of Defence: 2017-11-30
Disputation: Torsdagen den 30 november 2017, kl. 9.00, Hörsal Arvid Carlsson, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Natural killer cells
Acute myeloid leukemia
Immunotherapy
Killer-cell imunoglobulin-like receptor
Human leukocyte antigen class I molecules
Abstract: Natural killer (NK) cells are lymphocytes endowed with cytotoxicity against aberrant cells, including transformed and virus-infected cells. NK cell function is dictated by a fine-tuned interplay between activating and inhibitory receptors expressed on the NK cell surface. While the different activating receptors interact with unique ligands present on healthy or transformed cells, inhibitory NKG2A and killer immunoglobulin-like receptors (KIRs) invariably recognize HLA class I molecules. The pur... more
ISBN: 978-91-629-0339-8 (pdf)
978-91-629-0338-1 (print)
URI: http://hdl.handle.net/2077/52867
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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