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Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection


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Title: Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection
Authors: Waldenström, Jesper
E-mail: jesper.waldenstrom@vgregion.se
jesper.waldenstrom@gmail.com
Issue Date: 23-Apr-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Infectious Diseases
Parts of work: I. Rembeck K, Waldenstrom J, Hellstrand K, Nilsson S, Nystrom K, Martner A, et al. Variants of the inosine triphosphate pyrophosphatase gene are associated with reduced relapse risk following treatment for HCV genotype 2/3. Hepatology. 2014;59(6):2131-9.
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II. Waldenstrom J, Westin J, Nystrom K, Christensen P, Dalgard O, Farkkila M, et al. Randomized Trial Evaluating the Impact of Ribavirin Mono-Therapy and Double Dosing on Viral Kinetics, Ribavirin Pharmacokinetics and Anemia in Hepatitis C Virus Genotype 1 Infection. PLoS One. 2016;11(5):e0155142.
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III. Nystrom K, Wanrooij PH, Waldenstrom J, Adamek L, Brunet S, Said J, et al. Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus. J Virol. 2018;92(19).
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IV. Waldenstrom J, Kåberg M, Alanko-Blomé M, Widell A, Björkman P, Nilsson S, et al. I. Interferon-λ 4 Genetic Variants are Independently Associated with Spontaneous Clearance of Acute Hepatitis C Virus Genotype 1-3 Infection, and Inosine Triphosphate Pyrophosphatase Polymorphisms Impact on Immune Responses in Men. In Manuscript.
Date of Defence: 2020-05-15
Disputation: Fredagen den 15 maj 2020, kl 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg, https://gu-se.zoom.us/webinar/register/WN_B5-j3E6iSBeGzPU_r78puw
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Hepatitis C virus
HCV
Inosine triphosphate pyrophosphatase
ITPA
interferon-λ4
IFNL4
ribavirin
interferon
PWID
IP-10
Abstract: Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on interferon-α and ribavirin, but is now replaced by direct acting antivirals. Ribavirin is still used in the most difficult-to cure patients. This thesis evaluates host genetic variations in inosine triphosphate pyrophosphatase (ITPA) and interferon-λ4 (IFNL4) in relation to cure ... more
ISBN: 978-91-7833-844-3 (Print)
978-91-7833-845-0 (PDF)
URI: http://hdl.handle.net/2077/62223
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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