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Neuroinflammation and pain


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/35951

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Title: Neuroinflammation and pain
Authors: Block, Linda
E-mail: linda.block@vgregion.se
Issue Date: 5-Sep-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Anesthesiology & Intensive Care Medicine
Parts of work: I. Forshammar J, Block L, Lundborg C, Biber B, Hansson E (2011) Naloxone and ouabain in ultralow concentrations restore Na+/K+-ATPase and cytoskeleton in lipopolysaccharide-treated astrocytes. J Biol Chem 286:31586-31597.
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II. Block L, Forshammar J, Westerlund A, Björklund U, Lundborg C, Biber B, Hansson E (2012) Naloxone in ultralow concentration restores endomorphin-1-evoked Ca2+ signaling in lipopolysaccharide pretreated astrocytes. Neuroscience 205:1-9.
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III. Block L, Björklund U, Westerlund A, Jörneberg P, Biber B, Hansson E (2013) A new concept affecting restoration of inflammation-reactive astrocytes. Neuroscience 250:536-545.
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IV. Block L, Lundborg C, Bjersing J, Dahm P, Hansson E, Biber B. Ultralow dose of naloxone as an adjuvant to intrathecal morphine infusion improves perceived quality of sleep in patients with severe, persistent pain. A randomized, double-blind, placebo-controlled study. Submitted.
Date of Defence: 2014-09-26
Disputation: Fredagen den 26 september 2014, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Neuroinflammation
Pain
Persistant pain
Astrocytes
Morphine
Naloxone
Intrathecal administration
Abstract: ABSTRACT Background: Persistent pain that remains long after the physiological trigger has been resolved is a disabling condition. A possible mechanism for the transition from acute physiological pain to persistent pain involves low-grade inflammation in the central nervous system, in which inflammatory-activated astrocytes play a significant role. Aims: The aims of this thesis were to explore novel means for the restoration of inflammatory-activated astrocytes and to investigate whether such ... more
ISBN: 978-91-628-9101-5
978-91-628-9054-4
URI: http://hdl.handle.net/2077/35951
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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