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Mechanisms of Osseointegration: Experimental Studies on Early Cellular and Molecular Events in vivo
(2010-06-14)
The early cellular and molecular activities determining the early tissue response and bone formation at bone/implant interface are not fully understood. The general aim of the current thesis was to develop a model for ...
A methodological platform to study molecular biocompatibility of biomaterials. Experimental and clinical studies
(2016-05-13)
The aim of this project was to develop a methodological platform in order to advance our scientific understanding of the mechanisms of osseointegration. Screw-shaped, titanium implants, with different surface properties, ...
Osteocytes as indicators of bone quality - multiscale structure-composition characterisation of the bone-implant interface
(2017-09-01)
By virtue of certain design features, bone anchored metal implants can be made to elicit a strong initial osteogenic response, i.e., the amount of bone formed. While quantitative differences are often lost at longer follow ...
Multimodal and multiscale characterization of bone and bone interfaces in health and disease
(2023-05-16)
Seeing is believing. Our understanding of phenomena often involves their direct observation. However, bone architecture is challenging to visualize given its multi-level hierarchical organization. In this thesis, bone and ...