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A methodological platform to study molecular biocompatibility of biomaterials. Experimental and clinical studies


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Title: A methodological platform to study molecular biocompatibility of biomaterials. Experimental and clinical studies
Authors: Lennerås, Maria
E-mail: maria.lenneras@gu.se
Issue Date: 13-May-2016
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Biomaterials
Parts of work: Omar, Lennerås et al. Integrin and chemokine receptor gene expression in implant-adherent cells during early osseointegration. J Mater Sci Mater Med. 2010 Mar;21(3):969-80.
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Omar O, Lennerås ME et al. The correlation between gene expression of proinflammatory markers and bone formation during osseointegration with titanium implants. Biomaterials. 2011 Jan;32(2):374-86.
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Lennerås et al. Oxidized Titanium Implants Enhance Osseointegration via Mechanisms Involving RANK/RANKL/OPG Regulation. Clin Implant Dent Relat Res. 2015 Oct;17 Suppl 2:e486-500.
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Lennerås et al. Adhesion and activation of monocytes and MSCs on titanium surfaces analysed by FACS, qPCR and protein profiling. In manuscript

Lennerås, Tsikandylakis et al. The clinical, radiological, microbiological and molecular profile of the skin-penetration site of transfemoral amputees treated with bone-anchored prostheses. In manuscript.
Date of Defence: 2016-06-08
Disputation: Onsdagen den 8 juni 2016, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Osseointegration
titanium
inflammation
cell recruitment
cell adhesion
bone regeneration
bone remodelling
gene expression
immunohistochemistry
histomorphometry
removal torque
ultrastructure
FACS
protein profiling
transfemoral amputation
abutment
percutaneous
bacteria
clinical signs
Abstract: The aim of this project was to develop a methodological platform in order to advance our scientific understanding of the mechanisms of osseointegration. Screw-shaped, titanium implants, with different surface properties, were inserted in the rat tibia, or incubated in mono- or co-culture of human monocytes and MSCs. After different time points, the implant-adherent cells or the peri-implant bone were harvested and processed for different analyses. For in-vivo studies, qPCR, immunohistochemistry,... more
ISBN: 978-91-628-9817-5
URI: http://hdl.handle.net/2077/41847
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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