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Osteocytes as indicators of bone quality - multiscale structure-composition characterisation of the bone-implant interface


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Title: Osteocytes as indicators of bone quality - multiscale structure-composition characterisation of the bone-implant interface
Authors: Shah, Furqan Ali
E-mail: furqan.ali.shah@biomaterials.gu.se
Issue Date: 1-Sep-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Biomaterials
Parts of work: I. Shah FA, Zanghellini E, Matic A, Thomsen P, Palmquist A. The Orientation of Nanoscale Apatite Platelets in Relation to Osteoblastic–Osteocyte Lacunae on Trabecular Bone Surface. Calcif Tissue Int. 2016;98:193-205.
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II. Shah FA, Lee BEJ, Tedesco J, Wexell CL, Persson C, Thomsen P, Grandfield K, Palmquist A. Micrometre-sized magnesium whitlockite crystals in micropetrosis of bisphosphonate-exposed human alveolar bone. Submitted for publication.

III. Shah FA, Palmquist A. Evidence that Osteocytes in Autogenous Bone Fragments can Repair Disrupted Canalicular Networks and Connect with Osteocytes in de novo Formed Bone on the Fragment Surface. Calcif Tissue Int. 2017;101:321-327.
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IV. Shah FA, Johansson ML, Omar O, Simonsson H, Palmquist A, Thomsen P. Laser-Modified Surface Enhances Osseointegration and Biomechanical Anchorage of Commercially Pure Titanium Implants for Bone-Anchored Hearing Systems. PLoS One. 2016;11:e0157504.
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V. Shah FA, Nilson B, Brånemark R, Thomsen P, Palmquist A. The bone-implant interface – nanoscale analysis of clinically retrieved dental implants. Nanomedicine. 2014;10:1729-37.
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VI. Shah FA, Wang X, Thomsen P, Grandfield K, Palmquist A. High-Resolution Visualization of the Osteocyte Lacuno- Canalicular Network Juxtaposed to the Surface of Nanotextured Titanium Implants in Human. ACS Biomater Sci Eng. 2015;1:305-313.
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VII. Shah FA, Snis A, Matic A, Thomsen P, Palmquist A. 3D printed Ti6Al4V implant surface promotes bone maturation and retains a higher density of less aged osteocytes at the bone-implant interface. Acta Biomater. 2016;30:357-367.
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VIII. Shah FA, Omar O, Suska F, Snis A, Matic A, Emanuelsson L, Norlindh B, Lausmaa J, Thomsen P, Palmquist A. Long- term osseointegration of 3D printed CoCr constructs with an interconnected open-pore architecture prepared by electron beam melting. Acta Biomater. 2016;36:296-309.
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Date of Defence: 2017-09-22
Disputation: Fredagen den 22 september 2017, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: 3D printing
apatite
biomaterials
biomineralisation
bone
bone quality
canaliculi
CoCr
collagen
electron beam melting
electron microscopy
implant
interface
in vivo
lacuna
micropetrosis
osseointegration
osteocyte
Raman spectroscopy
surface modification
Ti6Al4V
titanium
ultrastructure
whitlockite
Abstract: By virtue of certain design features, bone anchored metal implants can be made to elicit a strong initial osteogenic response, i.e., the amount of bone formed. While quantitative differences are often lost at longer follow up times, do differences in the initial osteogenic response lead to long-term alterations in bone quality? This thesis investigates osseointegration in terms of bone quality, with an emphasis on the osteocyte lacuno-canalicular network (Ot.LCN) in relation to compositional and... more
ISBN: 978-91-629-0260-5 (print)
978-91-629-0261-2 (pdf)
URI: http://hdl.handle.net/2077/52415
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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