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On the pathogenesis of infections associated with percutaneous osseointegrated orthopaedic implants


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Title: On the pathogenesis of infections associated with percutaneous osseointegrated orthopaedic implants
Authors: Zaborowska, Magdalena N
E-mail: magdalena.zaborowska@biomaterials.gu.se
Issue Date: 22-Nov-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Biomaterials
Parts of work: Zaborowska M, Welch K, Brånemark R, Khalilpour P, Engqvist H, Thomsen P, Trobos M. Bacteria-material surface interactions: methodological development for the assessment of implant surface induced antibacterial effects. Journal of biomedical materials re-search. Part B, Applied biomaterials, 2015; 103(1): 179-187
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Zaborowska M*, Tillander J*, Brånemark R, Hagberg L, Thomsen P, Trobos M. Biofilm formation and antimicrobial susceptibility of staphylococci and enterococci from osteomyelitis associated with percutaneous orthopaedic implants. Journal of biomedical materials research. Part B, Applied biomaterials, 2017; 105B(8): 2630-2640. * Equal contribution.
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Zaborowska M, Vazirisani F, Shah FA, Omar O. Ekström K, Tro-bos M, Thomsen P. Extracellular vesicles from S. epidermidis and S. aureus isolated from bone-anchored prostheses induce cytolysis and proinflammatory cytokine secretion. In manuscript.

Zaborowska M*, Taulé Flores C*, Vazirisani F, Thomsen P, Tro-bos M. Role of extracellular vesicles from Staphylococcus epidermidis on antibiotic tolerance, planktonic growth, and biofilm formation un-der antimicrobial selective pressure. In manuscript. * Equal contribution.
Date of Defence: 2018-12-14
Disputation: Fredagen den 14 december 2018, kl 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: osseointegration
amputation prosthesis
implant-associated infection
biofilm
staphylococci
extracellular vesicles
host defence
cytokines
cell death
Abstract: Orthopaedic implants enable the restitution of locomotor function and improve the quality of life of many people. However, biomaterial-associated infection may occur due to the propensity of microorganisms to adhere and colonize implant surfaces. The objective was to gain knowledge on the pathogenesis of infections associated with percutaneous osseointegrated implants for lower limb amputation prostheses. The aims were to design in vitro methods for the evaluation of antimicrobial surface proper... more
ISBN: 978-91-7833-219-9 (PRINT)
978-91-7833-220-5 (PDF)
URI: http://hdl.handle.net/2077/56926
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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