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Cerebrospinal fluid biomarkers and cognition in older adults
(2021-04-21)
Alzheimer’s disease (AD) is the most common type of dementia. The cause of the disease is unknown, but a substantial amount of evidence suggest that the disease is started by an imbalance in the production and clearance ...
Alzheimer's disease and vascular dementia in population-based studies
(2021-03-30)
Dementia, a clinical syndrome with several profiles and causes, is characterised by a decline in cognitive functions, including memory, learning, executive function, attention, language, and social ability. The most common ...
Tau fragments: role as biomarkers and in the pathogenesis of Alzheimer's disease and other tauopathies
(2019-09-10)
N-123 is part of the physiological tau turnover, the generation of tau N-224 was shown to have clinical relevance, being related to AD; N-224 tau showed significantly higher concentrations in AD CSF compared to control and was related to worsening...
CSF biomarkers in idiopathic normal pressure hydrocephalus- Diagnostics and pathophysiology
(2019-05-23)
Idiopathic normal pressure hydrocephalus (iNPH) is a disease of the elderly with enlarged ventricles despite a normal CSF pressure. Clinically, iNPH presents with gait- and balance disturbances, cognitive decline and ...
Evaluation of the Endo-Lysosomal System and the Ubiquitin-Proteasome System in Neurodegenerative Diseases
(2018-02-27)
Neurodegeneration is the process of neuronal cell loss where the symptoms will reflect the regions affected. Neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s disease (PD) and frontotemporal ...
The role of microglia in Alzheimer's disease - Investigating mechansims regulating amyloid-β clearance
(2016-05-31)
Alzheimer’s disease (AD) is the most common form of dementia today. The disease is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain, accompanied by a progressive neurodegeneration ...
Quantitative neuroproteomics for biomarker discovery in Alzheimer's disease
(2014-01-17)
Alzheimer’s disease (AD) is the most common form of dementia characterized by amyloid plaques and neurofibrillary tangles in the brain. Novel biomarkers for AD are needed that reflect disease progression and could identify ...
CSF biomarkers reflecting beta-amyloid and axonal pathology in Alzheimer's disease and related conditions
(2011-11-18)
Cerebrospinal fluid (CSF) biomarkers may be used to identify and monitor pathological processes in the central nervous system. CSF biomarkers in Alzheimer’s disease (AD) include β-amyloid 42 (Aβ42), total-tau (T-tau) and ...
Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and Vascular dementia
(2011-05-27)
Patients suffering from mild cognitive impairment (MCI) run a higher risk of developing dementia, with Alzheimer’s disease (AD) being the most common form. Vascular dementia (VaD) is proposed to be the second most common ...
Proteomic strategies for analysis of cerebrospinal fluid in neurodegenerative disorders
(2008-04-04)
ABSTRACT
There is a great need for biomarkers to diagnose neurodegenerative disorders, such as the cognitive disorders Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Cerebrospinal fluid (CSF) is in contact ...