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Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and Vascular dementia


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Title: Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and Vascular dementia
Authors: Bjerke, Maria
E-mail: maria.bjerke@neuro.gu.se
Issue Date: 27-May-2011
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: I. Bjerke M, Andreasson U, Rolstad S, Nordlund A, Lind K, Zetterberg H, Edman A, Blennow K, Wallin A. Subcortical vascular dementia biomarker pattern in mild cognitive impairment. Dement Geriatr Cogn Disord. 2009;28(4):348-56. Epub 2009 Oct 27.
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II. Bjerke M, Portelius E, Minthon L, Wallin A, Anckarsäter H, Anckarsäter R, Andreasen N, Zetterberg H, Andreasson U, Blennow K. Confounding factors influencing amyloid Beta concentration in cerebrospinal fluid. Int J Alzheimers Dis. 2010 Jul 15;2010.
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III. Bjerke, M; Zetterberg, H; Edman, Å; Blennow, K; Wallin, A; Andreasson, U. Cerebrospinal fluid matrix metalloproteinases in combination with markers reflecting subcortical and cortical alterations differentiate between Vascular dementia and Alzheimer’s disease. Manuscript submitted

IV. Bjerke, M; Zetterberg, H; Edman, Å; Magdalena Nutu; Blennow, K; Wallin, A; Andreasson, U. A novel β-secretase activity correlates with amyloid precursor protein metabolites in cerebrospinal fluid of Vascular dementia and Alzheimer’s disease. Manuscript
Date of Defence: 2011-06-09
Disputation: Torsdagen den 9 juni 2011, kl. 13.00, Aulan i V-huset, Mölndals sjukhus
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Vascular dementia
Alzheimer's disease
biomarkers
cerebrospinal fluid
Abstract: Patients suffering from mild cognitive impairment (MCI) run a higher risk of developing dementia, with Alzheimer’s disease (AD) being the most common form. Vascular dementia (VaD) is proposed to be the second most common dementia entity, and it includes the clinically relatively homogenous subgroup of subcortical vascular dementia (SVD). Varying degrees of concomitant vascular lesions represent a link between AD and VaD, comprising a state of mixed dementia (MD). Biochemical markers provide impo... more
ISBN: 978-91-628-8312-6
URI: http://hdl.handle.net/2077/24854
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

 

 

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