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Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence
(2011-02-02)
Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter ...
Acute and chronic effects by stimulants on behavior and striatal neurotransmission in the rat
(2017-08-18)
Nicotine and amphetamines are the most widely abused stimulants. The main aim of the studies in this thesis was to investigate how these two drugs of abuse affect distinct regions of the rat brain involved in development ...
Glycine receptors in the central nervous system - development, distribution and relation to actions of alcohol
(2012-11-14)
The widespread consumption of alcohol and the great socioeconomic impact of alcohol abuse and addiction have contributed to the extensive investigations of this substance. Despite great efforts there is still uncertainty ...
Ethanol-induced modulation of dopamine transmission and synaptic activity in striatal subregions - focus on inhibitory receptors
(2015-04-17)
Background: Alcoholism is a chronic brain disease, affecting neurocircuitries involved in reward and learning. The rewarding effects of alcohol (ethanol) are believed to result from increased dopamine levels in the nucleus ...