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Acute and chronic effects by stimulants on behavior and striatal neurotransmission in the rat


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/52412

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Title: Acute and chronic effects by stimulants on behavior and striatal neurotransmission in the rat
Authors: Lotfi Moghaddam, Amir
E-mail: amir.lotfi@neuro.gu.se
Issue Date: 18-Aug-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: I. Lotfi A*, Licheri V*, Patton MH, Lagström O, Mathur B, Ericson M, Söderpalm B, Adermark L. Long-lasting inhibition of striatal excitability following nicotine exposure ex vivo (manuscript)

II. Adermark L, Morud J, Lotfi A, Jonsson S, Söderpalm B, Ericson M. Age-contingent influence over accumbal neurotransmission and the locomotor stimulatory response to acute and repeated administration of nicotine in Wistar rats Neuropharmacology. 2015, 97:104-12
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III. Adermark L, Morud J, Lotfi A, Danielsson K, Ulenius L, Söderpalm B, Ericson M. Temporal rewiring of striatal circuits initiated by nicotine Neuropsychopharmacology. 2016, 41:3051-3059
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IV. Lotfi A, Licheri V, Lagström O, Söderpalm B, Ericson M, Adermark L. Temporal and spatial suppression of striatal excitability elicited by amphetamine in Wistar rats (manuscript)
Date of Defence: 2017-09-15
Disputation: Fredagen den 15 september 2017, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: withdrawal
nicotine
amphetamine
striatum
GABA
glutamate
dopamine
sensitization
locomotor activity
Abstract: Nicotine and amphetamines are the most widely abused stimulants. The main aim of the studies in this thesis was to investigate how these two drugs of abuse affect distinct regions of the rat brain involved in development of habitual and compulsive behavior, namely subregions of striatum in the rat. To this end, using a battery of tests including behavior, brain slice electrophysiology, and molecular biology, we have evaluated acute effects by nicotine and amphetamine, as well as progressive chan... more
ISBN: 978-91-629-0189-9 (print)
978-91-629-0190-5 (pdf)
URI: http://hdl.handle.net/2077/52412
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

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