Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Title
Now showing items 135-154 of 480
-
Discovering the capabilities of ageing persons who are born abroad: crossing norms, moving health promotion forward
(2015-01-30)To improve the possibilities for the whole population to take control over their health is an important goal for health promotion and public health. Yet, with improved possibilities for international migration and extended ... -
DNA methylation profiling of CNS tumors; implications for clinical diagnostics
(2022-10-05)Diffuse gliomas and meningiomas are the most common primary tumors of the central nervous system (CNS) in adults and these tumors cause significant morbidity and mortality worldwide. Deregulation of the epigenetic mechanisms, ... -
Dopamine and the regulation of movements - significance of nigral and striatal dopamine release in normal, hemiparkinsonian and dyskinetic rats
(2009-02-02)Introduction: The nigrostriatal dopamine (DA) containing neurones are a pivotal component in the basal ganglia, a network that regulates movement. Degeneration of these neurones causes the cardinal symptoms of Parkinson’s ... -
Dopaminergic lnterference for Treatment of Schizophrenia and Alcohol Use Disorder - an experimental study in rats
(2022-05-27)The neurotransmitter dopamine is involved in several different physiological functions as well as pathological conditions. Two conditions that have been suggested to be related to a low dopaminergic tone in the ventral ... -
Dopaminergic stabilizers for the treatment of schizophrenia. Rat studies focusing on negative symptoms and mechanisms of action
(2007-11-21)Schizophrenia is a severe mental disorder manifested by positive, negative and cognitive symptoms. Current antipsychotic drugs have poor effects on negative and cognitive symptoms, thus necessitating the development of new ... -
Early detection of ESSENCE in Japanese 0-4-year-olds. Studies of neurodevelopmental problems in the community and in clinics
(2018-02-14)BACKGROUND: Early identification of children with neurodevelopmental problems/ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations) is a critical issue both in the community and in clinical ... -
Early identification of primary health care patients at risk of sick leave due to work-related stress
(2023-03-02)Aim: Work-related stress and sick leave are common among primary health care patients, and general practitioners (GPs) often handle cases involving stress and work capacity in their daily practices. This thesis aimed to ... -
Eating disorders, eating pathology and ESSENCE
(2016-11-03)BACKGROUND: Eating and mealtime problems are among the most common problems in individuals with autism spectrum disorder (ASD). Despite this, no systematic way of exploring these problems has been available for persons ... -
The effect of astrocytes and reactive gliosis on neurogenesis and astrogenesis in mice
(2008-11-10)Astrocytes are the most common cell type in mammalian central nervous system (CNS). Glial fibrillary acidic protein (GFAP) and vimentin constitute intermediate filaments (known also as nanofilaments), a part of the ... -
The effect of massage for women with breast cancer
(2008-06-30)ABSTRACT Breast cancer is the most common type of cancer in females. The effect of massage in the field of oncology has been investigated to some extent. The present thesis explored the effect of light pressure effleurage ... -
Effects and experiences of exercise during pregnancy
(2015-09-25)Background: Recommendations regarding intensity, duration and type of exercise during pregnancy vary worldwide. Most research on exercise during pregnancy investigates the effects of aerobic exercise while only a few trials ... -
Effects of dietary fatty acids on the immune system
(2015-11-11)Sepsis is a deadly disease with an increasing incidence worldwide. Today, antimicrobials are the only effective pharmacological treatment. At the same time, bacteria, the pathogens behind most cases of sepsis, are becoming ... -
Effects of epidermal growth factor on adult neural stem cells
(2013-11-04)In the adult brain neural stem cells are present in two discrete regions; the hippocampus and the subventricular zone (SVZ). The environment surrounding the stem and progenitor cells, the neurogenic niche, is integral for ... -
Effects of PGC1a-induced exercise adaptations in muscle on plasticity and recovery mechanisms in the CNS
(2019-05-17)In this thesis, we sought to determine if muscle-derived exercise-induced signaling via PGC-1α muscle activation influences neuroplasticity under physiological or pathophysiological conditions. For this purpose, transgenic ... -
Effects of prolactin on metabolism - changes induced by hyperprolactinemia
(2009-02-06)High prolactin levels during breast-feeding, is recognized to influence metabolism in order to supply glucose and fat for milk production. Pathologic overproduction of prolactin, hyperprolactinemia, is a condition primarily ... -
Effects of Psychosocial stress on DHEA and DHEA-S levels - Acute and Long-term effects
(2013-05-24)Background: Long-term psychosocial stress can cause and contribute to a wide range of psychological and somatic conditions, and accelerate aging. One of the consequences of long-term psychosocial stress may be a reduction in ... -
Electrically evoked compound action potentials as a tool for programming cochlear implants in children
(2023-05-03)Cochlear implants are generally the best treatment for young children with a profound hearing loss (or worse) when ordinary hearing aids cannot provide enough auditory stimulation. For these youngest recipients, there must ... -
Enriched, task specific therapy in the chronic phase after stroke
(2021-03-29)Recovery and improvement of motor functions and abilities after stroke depend on the spontaneous recovery process but also on the reorganization of neural mechanisms. In animal studies, an Enriched Environment (EE) has ... -
Epidemiological analysis of viral infections as risk factors for multiple sclerosis
(2009-06-16)Viral childhood diseases have been implicated in the pathogenesis of multiple sclerosis (MS). Swedish mass vaccination programmes resulted in radical changes in the panorama of the targeted infections. Vaccines against ...