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WISP-2 - A Novel Adipokine Related to Obesity and Insulin resistance
(2015-02-27)
Type 2 diabetes mellitus (T2D) is increasing worldwide at an epidemic rate and is expected to reach 592 million inflicted individuals by 2035 as compared to 382 million in 2013. Obesity is a major risk factor for insulin ...
Long-term effects of growth hormone replacement in hypopituitary adults on body composition, bone mass and cardiovascular risk factors
(2012-11-06)
Growth hormone (GH) deficient (GHD) adults have decreased bone mass and muscle strength, impaired body composition, disturbed serum lipid pattern and increased morbidity and mortality in cardiovascular and cerebrovascular ...
Regulation of vascular endothelial t-PA expression in inflammation: Potential target for pharmacological modulation
(2011-11-03)
The endogenous fibrinolytic system is important for preventing occluding thrombosis and subsequent tissue infarction. The main activator of the fibrinolytic system in the vascular compartment is tissue-type plasminogen ...
The physician and the sickness certification
(2018-01-18)
Background and aims: Sickness insurance is a hallmark of most welfare states. The rising costsof sickness insurance in Sweden have been attributed to varying sickness certification practices among physicians. Other factors, ...
Psoriatic arthritis: cardiovascular risk factors, health-related quality of life and effects of weight loss treatment
(2023-03-15)
Background: Psoriatic arthritis (PsA) is an inflammatory rheumatic disease, characterized by arthritis, dactylitis, enthesitis and sometimes axial disease. PsA is associated with several comorbidities and reduced health-related ...
Occupational heat exposure and kidney disease - Studies on the role of heat stress in the Mesoamerican epidemic of Chronic Kidney Disease of non-traditional origin
(2022-05-19)
This thesis examines the association between heat stress and kidney disease in Mesoamerica using different perspectives and methods. An ecologic study found that hot, sugarcane-cultivating regions had elevated chronic ...
Translational genetics identifies a novel target to treat fatty liver disease
(2023-02-09)
Fatty liver disease (FLD) is rapidly prevailing as the most common liver disease worldwide, with an estimated of one-quarter of the global population affected. Environmental and genetic determinants contribute to FLD ...
Physical activity and exercise in patients with intermittent claudication
(2022-09-26)
Introduction. Supervised exercise is a guideline recommendation in patients with intermittent claudication (IC). As the availability of supervised exercise varies, interest has turned to the more accessible home-based ...
Female sex hormones and health outcomes in women with specific focus on asthma
(2022-11-25)
In humans, gender differences exist across a wide spectrum of diseases. For instance, women are more likely to develop Sjogren’s syndrome, systemic lupus erythematosus, and autoimmune thyroid disease compared to men. On ...
The role of galectin-1 in type 2 diabetes. Clinical and experimental studies
(2022-05-27)
Aim: The purpose of this thesis was to identify a new agent in the subcutaneous adipose tissue and assess its clinical potential in the context of type 2 diabetes.
Study I: Through a combination of microdialysis and ...