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Pan-cancer study of transcriptional responses to oncogenic somatic mutations
(2021-05-27)
Cancer cells typically carry acquired somatic mutations in key cancer driver genes, which can be identified on the basis of recurrence in cancer cohorts. Such mutations may cause aberrant protein activity and altered gene ...
Computational studies of mutational sequence signatures in cancer genomes
(2021-10-08)
Cancer typically forms when mutational processes modify key cancer driver genes, resulting in positive selection and tumor growth. As such, mutational processes are at the core of the disease. Trinucleotide mutational ...
Molecular and genetic studies in high-risk neuroblastoma
(2021-02-04)
Neuroblastoma is the most common and deadly cancer in the first year of life. Children with high-risk neuroblastoma have a very poor prognosis, despite heavy multimodal treatment, with less than 50% of 5 years of overall ...
Molecular and genetic studies of DLG2 in neuroblastoma and colorectal cancer
(2022-05-19)
Neuroblastoma is one of the most common extra cranial solid tumors in children. It is one of the most common causes of death amongst the pediatric malignancies. There is however a large difference between the low risk ...